Tbio NFRKB Nuclear factor related to kappa-B-binding protein

Protein Summary

Description

Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex.

Uniprot Accession IDs

• Q6P4R8
• Q12869
• Q15312
• Q9H048

Gene Name

• NFRKB

Ensembl ID

• ENST00000446488
• ENSP00000400476
• ENSG00000170322
• ENST00000524746
• ENSP00000433572
• ENST00000524794
• ENSP00000436926

Symbol

• INO80G
• INO80G

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.97
histone modification site profile	0.85
disease perturbation	0.68
tissue sample	0.67
cellular component	0.6

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Nuclear Factor Related To Kappa-b-binding Protein

Protein / Nucleic Acid Binding / Nuclear Factor Related To Kappa-b-binding Protein

DTO Classes

Protein / Nucleic Acid Binding / Nuclear Factor Related To Kappa-b-binding Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.88   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 108   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.88   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0