You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
NFRKB
Nuclear factor related to kappa-B-binding protein

Protein Summary
Description
Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000446488
  • ENSP00000400476
  • ENSG00000170322
  • ENST00000524746
  • ENSP00000433572
  • ENST00000524794
  • ENSP00000436926

Symbol
  • INO80G
  • INO80G
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.97
histone modification site profile
0.85
disease perturbation
0.68
tissue sample
0.67
cellular component
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.38   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 108   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.38   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
63
reticulocyte count
2
1
2
18.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
63
reticulocyte count
2
18.8
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (33)
DNA Damage Recognition in GG-NER (R-HSA-5696394)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Damage Recognition in GG-NER
Reactome
DNA Repair
Reactome
Deubiquitination
Reactome
Global Genome Nucleotide Excision Repair (GG-NER)
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
DNA Damage Recognition in GG-NER
DNA Repair
Deubiquitination
Global Genome Nucleotide Excision Repair (GG-NER)
Metabolism of proteins
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (82)
1 – 10 of 82
RUVBL2
Tbio
Novelty: 0.01129017
p_int: 0.99999939
p_ni: 6.1e-7
Score: 0.929
Data Source: BioPlex,STRINGDB
RUVBL1
Tbio
Novelty: 0.0089115
p_int: 0.999999382
p_ni: 6.18e-7
Score: 0.985
Data Source: BioPlex,STRINGDB
INO80
Tbio
Family: Enzyme
Novelty: 0.09412936
p_int: 0.999999185
p_ni: 8.15e-7
Score: 0.997
Data Source: BioPlex,STRINGDB
UCHL5
Tbio
Family: Enzyme
Novelty: 0.01486265
p_int: 0.999999082
p_ni: 9.18e-7
Score: 0.997
Data Source: BioPlex,STRINGDB
INO80C
Tdark
Novelty: 0.04242834
p_int: 0.999998526
p_ni: 0.000001474
Score: 0.939
Data Source: BioPlex,STRINGDB
CCNDBP1
Tbio
Novelty: 0.01527762
p_int: 0.999971932
p_ni: 0.000028068
Score: 0.524
Data Source: BioPlex,STRINGDB
BCL7C
Tdark
Novelty: 0.31203802
p_int: 0.999961547
p_ni: 0.000038453
Score: 0.152
Data Source: BioPlex,STRINGDB
KPTN
Tbio
Novelty: 0.06841936
p_int: 0.999863347
p_ni: 0.000136653
Data Source: BioPlex
IL20RA
Tbio
Novelty: 0.02416816
p_int: 0.999245718
p_ni: 0.000754282
Data Source: BioPlex
MANSC1
Tdark
Novelty: 0.91681036
p_int: 0.998865597
p_ni: 0.001134403
Data Source: BioPlex
Publication Statistics
PubMed Score  8.38

PubMed score by year
PubTator Score  8.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer