Tbio FAM173B Protein N-lysine methyltransferase FAM173B

Protein Summary

Description

Mitochondrial protein-lysine N-methyltransferase that promotes chronic pain (PubMed:29444090). Involved in persistent inflammatory and neuropathic pain: methyltransferase activity in the mitochondria of sensory neurons promotes chronic pain via a pathway that depends on the production of reactive oxygen species (ROS) and on the engagement of spinal cord microglia (PubMed:29444090). Protein-lysine N-methyltransferase activity is dependent on S-adenosyl-L-methionine (PubMed:29444090). Target proteins are unknown (PubMed:29444090).

Uniprot Accession IDs

• Q6P4H8
• B4DT41
• B4DXK2
• E9PBZ4
• hFAM173B

Gene Name

• FAM173B

Ensembl ID

• ENST00000510047
• ENSP00000420876
• ENSG00000150756
• ENST00000511437
• ENSP00000422338

Symbol

• JS-2
• FAM173B
• hFAM173B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.76
histone modification site profile	0.72
transcription factor binding site profile	0.69
cell type or tissue	0.61
tissue sample	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.85   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 65   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.85   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0