You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ARHGAP11A
Rho GTPase-activating protein 11A

Protein Summary
Description
This gene encodes a member of the Rho GTPase activating protein family. In response to DNA damage, the encoded protein interacts with the p53 tumor suppressor protein and stimulates its tetramerization, which results in cell-cycle arrest and apoptosis. A chromosomal deletion that includes this gene is one cause of Prader-Willi syndrome, and an intronic variant of this gene may be associated with sleep duration in children. This gene is highly expressed in colon cancers and in a human basal-like breast cancer cell line. This gene also produces a ARHGAP11A-SCG5 readthrough transcript and ARHGAP11A-SCG5 protein. [provided by RefSeq, Feb 2019]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361627
  • ENSP00000355090
  • ENSG00000198826
  • ENST00000543522
  • ENSP00000440073
  • ENST00000565905
  • ENSP00000455754
  • ENST00000567348
  • ENSP00000454575
  • ENST00000611363
  • ENSP00000480085
  • ENSG00000275568
  • ENST00000619401
  • ENSP00000479117
  • ENST00000622253
  • ENSP00000481011
  • ENST00000633634
  • ENSP00000488640
  • ENSG00000282168

Symbol
  • KIAA0013
  • GAP (1-12)
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.78
transcription factor binding site profile
0.74
kinase perturbation
0.71
microRNA
0.67
cell line
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.39   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.39   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (162)
1 – 10 of 162
VTN
Tbio
Family:  TF
Novelty:  0.00046861
p_int:  0.799620527
p_ni:  0.000002654
p_wrong:  0.200376819
Score:  0.214
Data Source:  BioPlex,STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.943
Data Source:  STRINGDB
KIF11
Tchem
Novelty:  0.00170673
Score:  0.935
Data Source:  STRINGDB
BUB1
Tchem
Family:  Kinase
Novelty:  0.00327514
Score:  0.934
Data Source:  STRINGDB
RHOC
Tbio
Family:  Enzyme
Novelty:  0.00262213
Score:  0.932
Data Source:  STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.932
Data Source:  STRINGDB
RHOB
Tbio
Family:  Enzyme
Novelty:  0.0019205
Score:  0.93
Data Source:  STRINGDB
RAC2
Tbio
Family:  Enzyme
Novelty:  0.00116234
Score:  0.929
Data Source:  STRINGDB
RHOJ
Tbio
Family:  Enzyme
Novelty:  0.01217051
Score:  0.928
Data Source:  STRINGDB
RAC3
Tbio
Family:  Enzyme
Novelty:  0.02125361
Score:  0.928
Data Source:  STRINGDB
Pathways (3)
Rho GTPase cycle (R-HSA-194840)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
Rho GTPase cycle
Signal Transduction
Signaling by Rho GTPases
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
GWAS Traits (134)
Items per page:
1 – 5 of 134
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
7
0
1.1
97
8
7
0
1.1
97
1
4
0
1.1
94.8
1
4
0
1.1
94.8
synophrys measurement
1
1
1
76.8
Items per page:
1 – 5 of 134
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
97
0
1.1
97
0
1.1
94.8
0
1.1
94.8
synophrys measurement
1
76.8
Find similar targets by:
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rho GTPase activating protein 11A
VGNC:11816
453291
Macaque
Rho GTPase activating protein 11A
695823
Mouse
MGI:2444300
228482
Rat
RGD:1309107
296060
Dog
Rho GTPase activating protein 11A
487476
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rho GTPase activating protein 11A
Macaque
Rho GTPase activating protein 11A
Mouse
Rat
Dog
Rho GTPase activating protein 11A
Publication Statistics
PubMed Score 9.39
PubMed score by year
PubTator Score 7.23
PubTator score by year