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Tdark
FDX2
Ferredoxin-2, mitochondrial

Protein Summary
Description
Essential for heme A and Fe/S protein biosynthesis. This gene encodes a member of the ferredoxin family. The encoded protein contains a 2Fe-2S ferredoxin-type domain and is essential for heme A and Fe/S protein biosynthesis. Mutation in FDX1L gene is associated with mitochondrial muscle myopathy. [provided by RefSeq, Sep 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393708
  • ENSP00000377311
  • ENSG00000267673

Symbol
  • FDX1L
  • FDX1L
  • MEOAL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.78   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 7   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.78   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 7   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (41)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
ICAM-1 measurement
2
3
0
13.8
97.6
IGF-1 measurement
1
4
4
96.7
reticulocyte count
7
7
13
95.2
6
5
0
1.2
92
myeloid white cell count
2
2
2
91.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
ICAM-1 measurement
0
13.8
97.6
IGF-1 measurement
4
96.7
reticulocyte count
13
95.2
0
1.2
92
myeloid white cell count
2
91.5
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ferredoxin 2
VGNC:11074
455700
Mouse
MGI:1915415
68165
Rat
RGD:1561264
313786
Dog
ferredoxin 1 like
484957
Horse
ferredoxin 2 [Source:HGNC Symbol;Acc:HGNC:30546]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ferredoxin 2
Mouse
Rat
Dog
ferredoxin 1 like
Horse
ferredoxin 2 [Source:HGNC Symbol;Acc:HGNC:30546]
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q6P4F2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (15)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Cytochrome P450 - arranged by substrate type
Reactome
Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
Reactome
Disease
Reactome
Diseases of metabolism
Name
Explore in Pharos
Explore in Source
Biological oxidations
Cytochrome P450 - arranged by substrate type
Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
Disease
Diseases of metabolism
Gene Ontology Terms (7)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (71)
1 – 10 of 71
GFPT2
Tbio
Family:  Enzyme
Novelty:  0.01049877
p_int:  0.914168743
p_ni:  0.017438462
p_wrong:  0.068392796
Score:  0.563
Data Source:  BioPlex,STRINGDB
FDXR
Tbio
Family:  Enzyme
Novelty:  0.00171588
Score:  0.993
Data Source:  Reactome,STRINGDB
LYRM4
Tbio
Novelty:  0.03319832
Score:  0.985
Data Source:  STRINGDB
FXN
Tbio
Novelty:  0.00084064
Score:  0.981
Data Source:  STRINGDB
FDX1
Tbio
Novelty:  0.00124491
Score:  0.949
Data Source:  Reactome,STRINGDB
ISCU
Tbio
Novelty:  0.0043097
Score:  0.941
Data Source:  STRINGDB
NFS1
Tbio
Family:  Enzyme
Novelty:  0.01274706
Score:  0.915
Data Source:  STRINGDB
CYP11A1
Tclin
Family:  Enzyme
Novelty:  0.00096368
Score:  0.905
Data Source:  Reactome,STRINGDB
STAR
Tbio
Novelty:  0.0012662
Score:  0.9
Data Source:  STRINGDB
ISCA2
Tbio
Novelty:  0.02194373
Score:  0.882
Data Source:  STRINGDB
Publication Statistics
PubMed Score  16.78

PubMed score by year
PubTator Score  4.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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