Tbio CASC4 Protein CASC4

Protein Summary

Description

The increased expression level of this gene is associated with HER-2/neu proto-oncogene overexpression. Amplification and resulting overexpression of this proto-oncogene are found in approximately 30% of human breast and 20% of human ovarian cancers. Alternatively spliced variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Dec 2010]

Uniprot Accession IDs

• Q6P4E1
• B4DPZ6
• G5E934
• Q6UY45
• Q96EM1

Gene Name

• CASC4

Ensembl ID

• ENST00000299957
• ENSP00000299957
• ENSG00000166734
• ENST00000345795
• ENSP00000335063
• ENST00000557945
• ENSP00000453720

Symbol

• H63

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
histone modification site profile	0.87
kinase perturbation	0.84
microRNA	0.68
transcription factor binding site profile	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.74   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 85   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.74   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 85   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0