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Tdark
PLBD1
Phospholipase B-like 1

Protein Summary
Description
In view of the small size of the putative binding pocket, it has been proposed that it may act as an amidase or a peptidase (By similarity). Exhibits a weak phospholipase activity, acting on various phospholipids, including phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine and lysophospholipids.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000240617
  • ENSP00000240617
  • ENSG00000121316
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
transcription factor perturbation
0.94
PubMedID
0.82
disease perturbation
0.74
histone modification site profile
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.16   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 62   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.16   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 62   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (8)
Acyl chain remodelling of PC (R-HSA-1482788)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodelling of PC
Reactome
Acyl chain remodelling of PE
Reactome
Acyl chain remodelling of PI
Reactome
Glycerophospholipid biosynthesis
Reactome
Hydrolysis of LPC
Name
Explore in Pharos
Explore in Source
Acyl chain remodelling of PC
Acyl chain remodelling of PE
Acyl chain remodelling of PI
Glycerophospholipid biosynthesis
Hydrolysis of LPC
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (25)
1 – 10 of 25
PI4KA
Tchem
Family: Kinase
Novelty: 0.02976615
p_int: 0.999948187
p_ni: 0.000051812
Data Source: BioPlex
ZIC1
Tbio
Family: TF
Novelty: 0.00309271
p_int: 0.999940538
p_ni: 0.000059462
p_wrong: 1e-9
Data Source: BioPlex
TBC1D22B
Tbio
Novelty: 6
p_int: 0.999883576
p_ni: 0.000116421
p_wrong: 3e-9
Data Source: BioPlex
GMCL1
Tbio
Novelty: 0.1349742
p_int: 0.999869669
p_ni: 0.000130175
p_wrong: 1.56e-7
Data Source: BioPlex
CCDC51
Tdark
Novelty: 1.55555556
p_int: 0.9996655
p_ni: 0.0003345
Score: 0.191
Data Source: BioPlex,STRINGDB
VAV1
Tchem
Novelty: 0.00223848
p_int: 0.999614801
p_ni: 0.000385197
p_wrong: 2e-9
Score: 0.206
Data Source: BioPlex,STRINGDB
GPATCH2L
Tdark
Novelty: 4
p_int: 0.999601553
p_ni: 0.000398447
Score: 0.157
Data Source: BioPlex,STRINGDB
FTH1
Tbio
Novelty: 0.00088724
p_int: 0.998380998
p_ni: 0.00157675
p_wrong: 0.000042252
Data Source: BioPlex
IL31RA
Tbio
Novelty: 0.00114766
p_int: 0.998297289
p_ni: 0.001660125
p_wrong: 0.000042585
Data Source: BioPlex
SPICE1
Tbio
Novelty: 0.00199152
p_int: 0.975555026
p_ni: 0.024444448
p_wrong: 5.26e-7
Score: 0.211
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  2.16

PubMed score by year
PubTator Score  0.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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