Tbio MTFR2 Mitochondrial fission regulator 2

Protein Summary

Description

May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission (By similarity).

Uniprot Accession IDs

• Q6P444
• A8K8D8
• E1P585
• Q5JWR7
• Q6ZUE8
• Q7L3U6
• Q9BZ39

Gene Name

• MTFR2

Ensembl ID

• ENST00000367784
• ENSP00000356758
• ENSG00000146410
• ENST00000420702
• ENSP00000395232
• ENST00000451457
• ENSP00000407010

Symbol

• DUFD1
• FAM54A
• DUFD1
• FAM54A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.88
transcription factor binding site profile	0.73
tissue sample	0.61
transcription factor	0.59
cell type or tissue	0.55

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.28   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 58   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.28   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
intraocular pressure measurement	EFO_0004695	4	2	5		83
glaucoma	EFO_0000516	1	1	0	1.1	67.7
open-angle glaucoma	EFO_0004190	1	1	0	1.1	62.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
intraocular pressure measurement	EFO_0004695	5		83
glaucoma	EFO_0000516	0	1.1	67.7
open-angle glaucoma	EFO_0004190	0	1.1	62.1

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Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	mitochondrial fission regulator 2	VGNC:3495	747126
Macaque	mitochondrial fission regulator 2		106998139
Mouse	mitochondrial fission regulator 2	MGI:1919054	71804
Dog	mitochondrial fission regulator 2	VGNC:43470	483997
Cow	mitochondrial fission regulator 2	VGNC:31728	534254

Species	Name	OMA	EggNOG	Inparanoid
Chimp	mitochondrial fission regulator 2
Macaque	mitochondrial fission regulator 2
Mouse	mitochondrial fission regulator 2
Dog	mitochondrial fission regulator 2
Cow	mitochondrial fission regulator 2

Protein Structure (0 Structures, 1 AlphaFold Model)

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Representation

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Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q6P444-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (4)

Components (1)

Processes (3)

Find Similar Targets

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
mitochondrion	Inferred from Sequence or structural Similarity (ISS)	UniProtKB

Protein-Protein Interactions (66)

Explore Interacting Targets

1 – 10 of 66

• See Interactions on String-DB

ATG14

Tbio

Novelty:  0.00914791

p_int:  0.999987422

p_ni:  0.000012474

p_wrong:  1.05e-7

Data Source:  BioPlex

GABBR1

Tclin

Family:  GPCR

Novelty:  0.00086493

p_int:  0.99997012

p_ni:  0.000004486

p_wrong:  0.000025394

Data Source:  BioPlex

SCNN1D

Tbio

Family:  IC

Novelty:  0.06191685

p_int:  0.999943084

p_ni:  0.000056914

p_wrong:  2e-9

Score:  0.163

Data Source:  BioPlex,STRINGDB

TH

Tclin

Family:  Enzyme

Novelty:  0.00025719

p_int:  0.999933769

p_ni:  0.00006621

p_wrong:  2.1e-8

Score:  0.187

Data Source:  BioPlex,STRINGDB

SLC2A12

Tbio

Family:  Transporter

Novelty:  0.01455533

p_int:  0.999424357

p_ni:  0.000394648

p_wrong:  0.000180995

Data Source:  BioPlex

GUCY1B1

Tclin

Family:  Enzyme

Novelty:  0.03618378

p_int:  0.999333209

p_ni:  0.000064938

p_wrong:  0.000601853

Score:  0.188

Data Source:  BioPlex,STRINGDB

TMOD4

Tbio

Novelty:  0.00932697

p_int:  0.999110816

p_ni:  0.000032563

p_wrong:  0.000856621

Score:  0.163

Data Source:  BioPlex,STRINGDB

SIRT1

Tchem

Family:  Epigenetic

Novelty:  0.00022265

p_int:  0.885560005

p_ni:  0.114439995

Score:  0.185

Data Source:  BioPlex,STRINGDB

NPY2R

Tchem

Family:  GPCR

Novelty:  0.01177255

p_int:  0.840360499

p_ni:  0.000121304

p_wrong:  0.159518196

Data Source:  BioPlex

TTK

Tchem

Family:  Kinase

Novelty:  0.00447957

Score:  0.757

Data Source:  STRINGDB

Publication Statistics

PubMed Score  8.28

PubMed score by year

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PubTator Score  0.69

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Alternative splicing
Complete proteome
Mitochondrion
Phosphoprotein
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
glaucoma
intraocular pressure measurement
open-angle glaucoma