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Tdark
TTC27
Tetratricopeptide repeat protein 27

Protein Summary
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
cell type or tissue
0.78
transcription factor perturbation
0.68
transcription factor binding site profile
0.65
interacting protein
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.16   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.16   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Alopecia
1
3
3
76.9
blood protein measurement
1
1
1
40.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Alopecia
3
76.9
blood protein measurement
1
40.1
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tetratricopeptide repeat domain 27
VGNC:402
459142
Macaque
tetratricopeptide repeat domain 27
707021
Mouse
MGI:1921446
74196
Rat
RGD:1305264
298782
Horse
tetratricopeptide repeat domain 27
VGNC:24620
100054467
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tetratricopeptide repeat domain 27
Macaque
tetratricopeptide repeat domain 27
Mouse
Rat
Horse
tetratricopeptide repeat domain 27
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6P3X3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (149)
1 – 10 of 149
MTREX
Tbio
Novelty: 0.01358024
Score: 0.909
Data Source: STRINGDB
TBL3
Tdark
Novelty: 0.05195885
Score: 0.899
Data Source: STRINGDB
NOP2
Tbio
Family: Enzyme
Novelty: 0.01664777
Score: 0.881
Data Source: STRINGDB
CD2AP
Tbio
Novelty: 0.00603034
Score: 0.873
Data Source: STRINGDB
MAPK3
Tchem
Family: Kinase
Novelty: 0.00012969
Score: 0.869
Data Source: STRINGDB
PWP1
Tbio
Novelty: 0.07040539
Score: 0.866
Data Source: STRINGDB
NAT10
Tbio
Family: Enzyme
Novelty: 0.02453679
Score: 0.861
Data Source: STRINGDB
POLR1B
Tbio
Family: Enzyme
Novelty: 0.06955307
Score: 0.86
Data Source: STRINGDB
WDR3
Tbio
Novelty: 0.15410886
Score: 0.86
Data Source: STRINGDB
UTP18
Tdark
Novelty: 0.1719213
Score: 0.859
Data Source: STRINGDB
Publication Statistics
PubMed Score  1.16

PubMed score by year
PubTator Score  0.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer