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Tbio
DNAJC24
DnaJ homolog subfamily C member 24

Protein Summary
Description
Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron-bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta). Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH4 is 1 of several enzymes involved in synthesis of diphthamide in EEF2 (Liu et al., 2004 [PubMed 15485916]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000465995
  • ENSP00000417548
  • ENSG00000170946
  • ENST00000526042
  • ENSP00000435771

Symbol
  • DPH4
  • ZCSL3
  • DPH4
  • JJJ3
  • ZCSL3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
kinase perturbation
0.81
cell type or tissue
0.69
small molecule perturbation
0.66
microRNA
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.65   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.65   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (85)
1 – 10 of 85
EEF2
Tchem
Novelty:  0.00064095
Score:  0.966
Data Source:  STRINGDB
DPH2
Tbio
Novelty:  0.04268301
Score:  0.87
Data Source:  STRINGDB
DPH1
Tbio
Novelty:  0.02296024
Score:  0.85
Data Source:  STRINGDB
DPH7
Tbio
Family:  Enzyme
Novelty:  0.05925085
Score:  0.822
Data Source:  STRINGDB
DNAJC21
Tdark
Novelty:  0.05368949
Score:  0.818
Data Source:  STRINGDB
DPH3
Tdark
Novelty:  0.05288317
Score:  0.807
Data Source:  STRINGDB
DPH5
Tbio
Family:  Enzyme
Novelty:  0.09745698
Score:  0.805
Data Source:  STRINGDB
ELP4
Tbio
Novelty:  0.03734233
Score:  0.802
Data Source:  STRINGDB
IMMP1L
Tbio
Family:  Enzyme
Novelty:  0.16680031
Score:  0.785
Data Source:  STRINGDB
MPPED2
Tbio
Family:  Enzyme
Novelty:  0.091909
Score:  0.764
Data Source:  STRINGDB
Pathways (5)
Gamma carboxylation, hypusine formation and arylsulfatase activation (R-HSA-163841)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gamma carboxylation, hypusine formation and arylsulfatase activation
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Synthesis of diphthamide-EEF2
Name
Explore in Pharos
Explore in Source
Gamma carboxylation, hypusine formation and arylsulfatase activation
Metabolism of proteins
Post-translational protein modification
Synthesis of diphthamide-EEF2
Gene Ontology Terms (9)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
1
2
73.2
cortical surface area measurement
1
1
0
7.7
59.5
optic disc area measurement
2
2
3
59.4
erythrocyte count
1
1
1
56
sodium measurement
1
1
1
53.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
73.2
cortical surface area measurement
0
7.7
59.5
optic disc area measurement
3
59.4
erythrocyte count
1
56
sodium measurement
1
53.7
Find similar targets by:
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member C24
VGNC:11341
737351
Macaque
DnaJ heat shock protein family (Hsp40) member C24
696221
Mouse
MGI:1919522
99349
Rat
RGD:1564710
362184
Horse
DnaJ heat shock protein family (Hsp40) member C24 [Source:HGNC Symbol;Acc:HGNC:26979]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member C24
Macaque
DnaJ heat shock protein family (Hsp40) member C24
Mouse
Rat
Horse
DnaJ heat shock protein family (Hsp40) member C24 [Source:HGNC Symbol;Acc:HGNC:26979]
Publication Statistics
PubMed Score 7.65
PubMed score by year
PubTator Score 4.15
PubTator score by year