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Tbio
FBXO42
F-box only protein 42

Protein Summary
Description
Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation. Members of the F-box protein family, such as FBXO42, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (SKP1A; MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375592
  • ENSP00000364742
  • ENSG00000037637

Symbol
  • FBX42
  • JFK
  • KIAA1332
  • JFK
  • Fbx42
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.9
transcription factor binding site profile
0.85
disease perturbation
0.79
cell type or tissue
0.78
histone modification site profile
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.55   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 272   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.55   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 272   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
5
7
8
3.8
99.4
low density lipoprotein cholesterol measurement
5
3
5
88.3
aspartate aminotransferase measurement
2
2
1
13.2
83.6
body mass index
5
1
5
72.2
balding measurement
1
1
1
67.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
8
3.8
99.4
low density lipoprotein cholesterol measurement
5
88.3
aspartate aminotransferase measurement
1
13.2
83.6
body mass index
5
72.2
balding measurement
1
67.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
F-box protein 42
VGNC:52947
456474
Macaque
F-box protein 42
698061
Mouse
MGI:1924992
213499
Dog
F-box protein 42
VGNC:40782
478219
Horse
F-box protein 42
VGNC:17955
100053402
Species
Name
OMA
EggNOG
Inparanoid
Chimp
F-box protein 42
Macaque
F-box protein 42
Mouse
Dog
F-box protein 42
Horse
F-box protein 42
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6P3S6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (50)
1 – 10 of 50
RBPJ
Tchem
Family:  TF
Novelty:  0.00168834
p_int:  1
Score:  0.567
Data Source:  BioPlex,STRINGDB
GSK3A
Tclin
Family:  Kinase
Novelty:  0.00925708
p_int:  0.999935093
p_ni:  0.000064897
p_wrong:  1e-8
Score:  0.343
Data Source:  BioPlex,STRINGDB
ROCK2
Tclin
Family:  Kinase
Novelty:  0.00242311
p_int:  0.999775981
p_ni:  0.000224019
Score:  0.318
Data Source:  BioPlex,STRINGDB
CUL1
Tbio
Novelty:  0.00244476
p_int:  0.999679246
p_ni:  0.000320754
Score:  0.617
Data Source:  BioPlex,STRINGDB
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
p_int:  0.999674203
p_ni:  0.000325796
p_wrong:  2e-9
Score:  0.715
Data Source:  BioPlex,STRINGDB
RAB28
Tbio
Family:  Enzyme
Novelty:  0.08899319
p_int:  0.99957023
p_ni:  3e-8
p_wrong:  0.00042974
Score:  0.63
Data Source:  BioPlex,STRINGDB
CCDC6
Tbio
Novelty:  0.00702098
p_int:  0.995439649
p_ni:  0.004560351
Data Source:  BioPlex
CST1
Tbio
Novelty:  0.02399609
p_int:  0.98911974
p_ni:  0.006578109
p_wrong:  0.004302151
Data Source:  BioPlex
TTC9C
Tdark
Novelty:  0.85949913
p_int:  0.987568325
p_ni:  0.012431476
p_wrong:  1.98e-7
Data Source:  BioPlex
KLK6
Tchem
Family:  Enzyme
Novelty:  0.00488956
p_int:  0.941217559
p_ni:  0.05866974
p_wrong:  0.000112701
Score:  0.187
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  6.55

PubMed score by year
PubTator Score  3.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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