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Tbio
DENND1B
DENN domain-containing protein 1B

Protein Summary
Description
Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells (PubMed:20154091, PubMed:20937701, PubMed:24520163, PubMed:26774822). Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form (PubMed:20154091, PubMed:20937701). Plays a role in clathrin-mediated endocytosis (PubMed:20154091). Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity (PubMed:26774822). Dysregulation leads to impaired TCR down-modulation and recycling, affecting cytokine production in TH2 cells (PubMed:26774822). Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000235453
  • ENSP00000235453
  • ENSG00000213047
  • ENST00000367396
  • ENSP00000356366
  • ENST00000620048
  • ENSP00000479816

Symbol
  • C1orf218
  • FAM31B
  • FAM31B
  • C1ORF18
  • C1orf218
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.99
transcription factor perturbation
0.94
virus perturbation
0.92
transcription factor
0.78
histone modification site profile
0.77


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.6   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.6   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
unipolar depression
3
5
3
1
98.3
neuroticism measurement
4
7
2
5.9
96.2
depressive symptom measurement
3
3
3
94.4
worry measurement
2
5
2
6.9
90.8
2
2
0
1.1
80.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
unipolar depression
3
1
98.3
neuroticism measurement
2
5.9
96.2
depressive symptom measurement
3
94.4
worry measurement
2
6.9
90.8
0
1.1
80.9
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2447812
329260
Rat
RGD:1308441
289051
Dog
DENN domain containing 1B
VGNC:53340
490259
Opossum
DENN domain containing 1B
100026686
Platypus
DENN domain containing 1B
100074528
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
DENN domain containing 1B
Opossum
DENN domain containing 1B
Platypus
DENN domain containing 1B
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
RAB GEFs exchange GTP for GDP on RABs
Reactome
Rab regulation of trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
RAB GEFs exchange GTP for GDP on RABs
Rab regulation of trafficking
Vesicle-mediated transport
Protein-Protein Interactions (69)
1 – 10 of 69
SERPINA12
Tbio
Novelty: 0.00549132
p_int: 0.871256574
p_ni: 0.12872862
p_wrong: 0.000014806
Score: 0.527
Data Source: BioPlex,STRINGDB
RAB35
Tbio
Family: Enzyme
Novelty: 0.01514601
Score: 0.988
Data Source: Reactome,STRINGDB
DENND1A
Tbio
Novelty: 0.04823149
Score: 0.906
Data Source: STRINGDB
GDI1
Tbio
Novelty: 0.01710945
Score: 0.9
Data Source: Reactome,STRINGDB
AKT3
Tchem
Family: Kinase
Novelty: 0.00308931
Score: 0.9
Data Source: STRINGDB
CHM
Tbio
Family: Enzyme
Novelty: 0.00226278
Score: 0.9
Data Source: Reactome,STRINGDB
AKT1
Tchem
Family: Kinase
Novelty: 0.00003185
Score: 0.9
Data Source: STRINGDB
YWHAE
Tbio
Novelty: 0.00431876
Score: 0.9
Data Source: STRINGDB
GDI2
Tbio
Novelty: 0.02861013
Score: 0.9
Data Source: Reactome,STRINGDB
AKT2
Tchem
Family: Kinase
Novelty: 0.00167027
Score: 0.9
Data Source: STRINGDB
Publication Statistics
PubMed Score  13.60

PubMed score by year
PubTator Score  9.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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