Tbio DENND1B DENN domain-containing protein 1B

Protein Summary

Description

Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells (PubMed:20154091, PubMed:20937701, PubMed:24520163, PubMed:26774822). Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form (PubMed:20154091, PubMed:20937701). Plays a role in clathrin-mediated endocytosis (PubMed:20154091). Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity (PubMed:26774822). Dysregulation leads to impaired TCR down-modulation and recycling, affecting cytokine production in TH2 cells (PubMed:26774822). Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]

Uniprot Accession IDs

• Q6P3S1
• B5MD89
• D3PFD5
• Q5T3B8
• Q5T3B9
• Q5T3C1
• Q5TAI8
• Q6B0I8
• Q8NDT1
• Q8TBE6
• Q9H774
• Q9NXU2

Gene Name

• DENND1B

Ensembl ID

• ENST00000235453
• ENSP00000235453
• ENSG00000213047
• ENST00000367396
• ENSP00000356366
• ENST00000620048
• ENSP00000479816

Symbol

• C1orf218
• FAM31B
• FAM31B
• C1ORF18
• C1orf218

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.99
transcription factor perturbation	0.94
virus perturbation	0.92
transcription factor	0.78
histone modification site profile	0.77

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.86   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 145   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.86   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0