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Tchem
NEK5
Serine/threonine-protein kinase Nek5

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355568
  • ENSP00000347767
  • ENSG00000197168
  • ENST00000617045
  • ENSP00000477810
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
histone modification site profile
0.77
protein domain
0.73
tissue sample
0.58
small molecule
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.48   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.48   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (32)
FN3K
Tbio
Family:  Kinase
Novelty:  0.02600747
Score:  0.626
Data Source:  STRINGDB
TRIM36
Tbio
Family:  Enzyme
Novelty:  0.06724803
Score:  0.62
Data Source:  STRINGDB
CKAP2
Tbio
Novelty:  0.00345027
Score:  0.603
Data Source:  STRINGDB
CCDC65
Tdark
Novelty:  0.05107666
Score:  0.598
Data Source:  STRINGDB
CSRNP2
Tdark
Novelty:  0.95252026
Score:  0.587
Data Source:  STRINGDB
ACOT12
Tbio
Family:  Enzyme
Novelty:  0.04464523
Score:  0.562
Data Source:  STRINGDB
LRRC45
Tdark
Novelty:  0.38407505
Score:  0.55
Data Source:  STRINGDB
CCDC137
Tdark
Novelty:  1.16145052
Score:  0.516
Data Source:  STRINGDB
ANO4
Tbio
Novelty:  0.10053632
Score:  0.515
Data Source:  STRINGDB
GGA1
Tbio
Novelty:  0.00866392
Score:  0.513
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
52.4
mean corpuscular hemoglobin concentration
1
1
1
40.7
anti-chlamydia trachomatis antibody measurement
1
1
0
1.3
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
52.4
mean corpuscular hemoglobin concentration
1
40.7
anti-chlamydia trachomatis antibody measurement
0
1.3
15.8
Find similar targets by:
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NIMA related kinase 5
VGNC:7297
745999
Macaque
NIMA related kinase 5
713960
Mouse
MGI:2142824
330721
Rat
RGD:1593817
685440
Horse
NIMA related kinase 5
VGNC:20672
100052593
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NIMA related kinase 5
Macaque
NIMA related kinase 5
Mouse
Rat
Horse
NIMA related kinase 5
Publication Statistics
PubMed Score 10.48
PubMed score by year
PubTator Score 2.97
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title