Tbio CEP85 Centrosomal protein of 85 kDa

Protein Summary

Description

Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity (PubMed:26220856). This gene encodes a protein that belongs to the centrosome-associated family of proteins. The centrosome is a subcellular organelle in the animal cell that functions as a microtubule organizing center and is involved in cell-cycle progression. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• Q6P2H3
• B4DRL1
• D3DPK4
• F8W7K4
• Q5VY68
• Q5VY70
• Q9H6Q1
• Q9H828
• Q9UF52
• Cep85

Gene Name

• CEP85

Ensembl ID

• ENST00000252992
• ENSP00000252992
• ENSG00000130695
• ENST00000451429
• ENSP00000417002
• ENST00000640292
• ENSP00000492362

Symbol

• CCDC21
• CCDC21

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.8
transcription factor perturbation	0.74
tissue sample	0.7
small molecule perturbation	0.68
tissue	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.95   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 57   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.95   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0