Tbio MED27 Mediator of RNA polymerase II transcription subunit 27

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Mediator Of Rna Polymerase Ii Transcription Subunit 27

DTO Classes

Protein / Transcription Factor / Transcription Cofactor / Mediator Of Rna Polymerase Ii Transcription Subunit 27

Protein Summary

Description

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]

Uniprot Accession IDs

• Q6P2C8
• O95401
• Q4F964
• Q5VTA4
• Q5VTA5
• Q9BU57
• Q9NYR4
• V9GYV9

Gene Name

• MED27

Ensembl ID

• ENST00000292035
• ENSP00000292035
• ENSG00000160563
• ENST00000357028
• ENSP00000349530
• ENST00000474263
• ENSP00000477136

Symbol

• CRSP34
• CRSP8
• MED3
• CRSP8
• CRAP34
• CRSP34
• TRAP37

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.91
phenotype	0.82
interacting protein	0.81
gene perturbation	0.76
transcription factor binding site profile	0.74

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.57   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 141   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.57   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (11)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 11

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
self reported educational attainment	EFO_0004784	4	5	5	5.6	98.6
cognitive function measurement	EFO_0008354	3	3	4		95.7
mathematical ability	EFO_0004875	3	2	4		94.5
smoking status measurement	EFO_0006527	2	1	2		79.9
waist-hip ratio	EFO_0004343	1	1	1		62.8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 11

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
self reported educational attainment	EFO_0004784	5	5.6	98.6
cognitive function measurement	EFO_0008354	4		95.7
mathematical ability	EFO_0004875	4		94.5
smoking status measurement	EFO_0006527	2		79.9
waist-hip ratio	EFO_0004343	1		62.8

Reset Zoom  Beta Count   Odds Ratio

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	mediator complex subunit 27		715219
Mouse	mediator complex subunit 27	MGI:1916225	68975
Rat	mediator complex subunit 27	RGD:1564993	296612
Dog	mediator complex subunit 27	VGNC:43134	612800
Horse	mediator complex subunit 27	VGNC:20084	100069513

Species	Name	OMA	EggNOG	Inparanoid
Macaque	mediator complex subunit 27
Mouse	mediator complex subunit 27
Rat	mediator complex subunit 27
Dog	mediator complex subunit 27
Horse	mediator complex subunit 27

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q6P2C8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)

Reactome (9)

KEGG (1)

Developmental Biology (R-HSA-1266738)

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Items per page:

5

1 – 5 of 9

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of lipids	740 targets	R-HSA-556833

Name	Explore in Pharos	Explore in Source
Developmental Biology	1055 targets	R-HSA-1266738
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
Metabolism	2112 targets	R-HSA-1430728
Metabolism of lipids	740 targets	R-HSA-556833

Gene Ontology Terms (12)

Functions (2)

Components (7)

Processes (3)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
transcription coactivator activity	Inferred from Direct Assay (IDA)	UniProtKB
ubiquitin protein ligase activity	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (85)

Explore Interacting Targets

1 – 10 of 85

• See Interactions on String-DB

MED21

Tbio

Family: Enzyme

Novelty: 0.06996616

p_int: 0.999999979

p_ni: 2e-8

p_wrong: 1e-9

Score: 0.99

Data Source: BioPlex,STRINGDB

MED17

Tbio

Family: Enzyme

Novelty: 0.02984503

p_int: 0.999999964

p_ni: 3.6e-8

Score: 0.998

Data Source: BioPlex,STRINGDB

MED18

Tbio

Family: Enzyme

Novelty: 0.04066825

p_int: 0.999999952

p_ni: 4.8e-8

Score: 0.999

Data Source: BioPlex,STRINGDB

MED28

Tbio

Family: Enzyme

Novelty: 0.00362108

p_int: 0.999999903

p_ni: 9.7e-8

Score: 0.999

Data Source: BioPlex,STRINGDB

MED19

Tbio

Family: Enzyme

Novelty: 0.03926689

p_int: 0.999999775

p_ni: 2.25e-7

Score: 0.997

Data Source: BioPlex,STRINGDB

MED20

Tbio

Family: Enzyme

Novelty: 0.02039559

p_int: 0.999999605

p_ni: 3.95e-7

Score: 0.996

Data Source: BioPlex,STRINGDB

CCNC

Tbio

Novelty: 0.00585842

p_int: 0.999999009

p_ni: 9.91e-7

Score: 0.994

Data Source: BioPlex,STRINGDB

MED1

Tbio

Family: Enzyme

Novelty: 0.00852082

p_int: 0.999998696

p_ni: 0.000001304

Score: 0.999

Data Source: BioPlex,STRINGDB

MED10

Tdark

Family: Enzyme

Novelty: 0.02988632

p_int: 0.999998594

p_ni: 0.000001406

Score: 0.996

Data Source: BioPlex,STRINGDB

MED7

Tbio

Family: Enzyme

Novelty: 0.04773947

p_int: 0.999997354

p_ni: 0.000002646

Score: 0.998

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  37.57

PubMed score by year

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PubTator Score  23.73

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

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UniProt Keyword Find Similar Targets

Activator
Alternative splicing
Complete proteome
Methylation
Nucleus
Phosphoprotein
Reference proteome
Transcription
Transcription regulation

GWAS Trait Find Similar Targets

cognitive function measurement
insomnia measurement
intelligence
lifestyle measurement
mathematical ability
self reported educational attainment
smoking initiation
smoking status measurement
triglyceride measurement
type II diabetes mellitus