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Tbio
MED27
Mediator of RNA polymerase II transcription subunit 27

Protein Summary
Description
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit comp ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292035
  • ENSP00000292035
  • ENSG00000160563
  • ENST00000357028
  • ENSP00000349530
  • ENST00000474263
  • ENSP00000477136

Symbol
  • CRSP34
  • CRSP8
  • MED3
  • CRSP8
  • CRAP34
  • CRSP34
  • TRAP37
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
phenotype
0.82
interacting protein
0.81
gene perturbation
0.76
transcription factor binding site profile
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.57   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 141   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.57   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
5
5
5.6
98.6
cognitive function measurement
3
3
4
95.7
mathematical ability
3
2
4
94.5
smoking status measurement
2
1
2
79.9
waist-hip ratio
1
1
1
62.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
5
5.6
98.6
cognitive function measurement
4
95.7
mathematical ability
4
94.5
smoking status measurement
2
79.9
waist-hip ratio
1
62.8
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
mediator complex subunit 27
715219
Mouse
MGI:1916225
68975
Rat
RGD:1564993
296612
Dog
mediator complex subunit 27
VGNC:43134
612800
Horse
mediator complex subunit 27
VGNC:20084
100069513
Species
Name
OMA
EggNOG
Inparanoid
Macaque
mediator complex subunit 27
Mouse
Rat
Dog
mediator complex subunit 27
Horse
mediator complex subunit 27
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6P2C8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Developmental Biology
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism
Metabolism of lipids
Protein-Protein Interactions (85)
1 – 10 of 85
MED21
Tbio
Family: Enzyme
Novelty: 0.06996616
p_int: 0.999999979
p_ni: 2e-8
p_wrong: 1e-9
Score: 0.99
Data Source: BioPlex,STRINGDB
MED17
Tbio
Family: Enzyme
Novelty: 0.02984503
p_int: 0.999999964
p_ni: 3.6e-8
Score: 0.998
Data Source: BioPlex,STRINGDB
MED18
Tbio
Family: Enzyme
Novelty: 0.04066825
p_int: 0.999999952
p_ni: 4.8e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
MED28
Tbio
Family: Enzyme
Novelty: 0.00362108
p_int: 0.999999903
p_ni: 9.7e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
MED19
Tbio
Family: Enzyme
Novelty: 0.03926689
p_int: 0.999999775
p_ni: 2.25e-7
Score: 0.997
Data Source: BioPlex,STRINGDB
MED20
Tbio
Family: Enzyme
Novelty: 0.02039559
p_int: 0.999999605
p_ni: 3.95e-7
Score: 0.996
Data Source: BioPlex,STRINGDB
CCNC
Tbio
Novelty: 0.00585842
p_int: 0.999999009
p_ni: 9.91e-7
Score: 0.994
Data Source: BioPlex,STRINGDB
MED1
Tbio
Family: Enzyme
Novelty: 0.00852082
p_int: 0.999998696
p_ni: 0.000001304
Score: 0.999
Data Source: BioPlex,STRINGDB
MED10
Tdark
Family: Enzyme
Novelty: 0.02988632
p_int: 0.999998594
p_ni: 0.000001406
Score: 0.996
Data Source: BioPlex,STRINGDB
MED7
Tbio
Family: Enzyme
Novelty: 0.04773947
p_int: 0.999997354
p_ni: 0.000002646
Score: 0.998
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  37.57

PubMed score by year
PubTator Score  23.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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