Tbio MED27 Mediator of RNA polymerase II transcription subunit 27

Protein Summary

Description

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]

Uniprot Accession IDs

• Q6P2C8
• O95401
• Q4F964
• Q5VTA4
• Q5VTA5
• Q9BU57
• Q9NYR4
• V9GYV9

Gene Name

• MED27

Ensembl ID

• ENST00000292035
• ENSP00000292035
• ENSG00000160563
• ENST00000357028
• ENSP00000349530
• ENST00000474263
• ENSP00000477136

Symbol

• CRSP34
• CRSP8
• MED3
• CRSP8
• CRAP34
• CRSP34
• TRAP37

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.91
phenotype	0.82
interacting protein	0.81
gene perturbation	0.76
transcription factor binding site profile	0.74

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Mediator Of Rna Polymerase Ii Transcription Subunit 27

DTO Classes

Protein / Transcription Factor / Transcription Cofactor / Mediator Of Rna Polymerase Ii Transcription Subunit 27

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.75   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 141   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.75   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0