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Tbio
TAF2
Transcription initiation factor TFIID subunit 2

Protein Summary
Description
Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. It requires core promoter-specific cofactors for productive transcription stimulation. TAF2 stabilizes TFIID binding to core promoter. Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378164
  • ENSP00000367406
  • ENSG00000064313

Symbol
  • CIF150
  • TAF2B
  • MRT40
  • TAF2B
  • CIF150
  • TAFII150
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
co-expressed gene
0.89
hub protein
0.82
interacting protein
0.7
molecular function
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.38   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.38   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (22)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
HIV Infection
Reactome
HIV Life Cycle
Name
Explore in Pharos
Explore in Source
Disease
Gene expression (Transcription)
Generic Transcription Pathway
HIV Infection
HIV Life Cycle
Protein-Protein Interactions (117)
1 – 10 of 117
TAF8
Tbio
Novelty: 0.01056638
p_int: 0.999999988
p_ni: 1.2e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
SPATA25
Tbio
Novelty: 0.80142563
p_int: 0.999999946
p_ni: 5.4e-8
Data Source: BioPlex
TAF7L
Tbio
Novelty: 0.08132691
p_int: 0.999999882
p_ni: 1.03e-7
p_wrong: 1.5e-8
Score: 0.994
Data Source: BioPlex,STRINGDB
TAF12
Tbio
Novelty: 0.04352637
p_int: 0.999999533
p_ni: 4.67e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
RFC4
Tbio
Novelty: 0.03232586
p_int: 0.975272611
p_ni: 0.024727125
p_wrong: 2.64e-7
Score: 0.252
Data Source: BioPlex,STRINGDB
AK9
Tbio
Family: Kinase
Novelty: 0.06306357
p_int: 0.856569297
p_ni: 0.061336203
p_wrong: 0.0820945
Score: 0.209
Data Source: BioPlex,STRINGDB
HDGFL2
Tbio
Family: Epigenetic
Novelty: 0.11846257
p_int: 0.843637011
p_ni: 0.156351481
p_wrong: 0.000011508
Data Source: BioPlex
RGS2
Tbio
Novelty: 0.00370571
p_int: 0.79915765
p_ni: 0.136331022
p_wrong: 0.064511328
Score: 0.232
Data Source: BioPlex,STRINGDB
TBP
Tbio
Novelty: 0.00034941
Score: 0.999
Data Source: STRINGDB
TAF5
Tbio
Novelty: 0.05443551
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  23.38

PubMed score by year
PubTator Score  17.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer