Tbio METTL2B Methyltransferase-like protein 2B

Protein Summary

Description

Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification of some tRNAs. This gene is a member of a family of methyltransferases that share homology with, but are distinct from, the UbiE family of methyltransferases. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q6P1Q9
• B4DZ68
• Q0IJ54
• Q3B7J1

Gene Name

• METTL2B

Ensembl ID

• ENST00000262432
• ENSP00000262432
• ENSG00000165055
• ENST00000480046
• ENSP00000418402

Symbol

• METL
• METTL2
• METTL2A
• PSENIP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.95
cellular component	0.84
histone modification site profile	0.77
cell type or tissue	0.67
virus perturbation	0.64

Protein Classes

PANTHER Classes

Protein / Transferase / Methyltransferase / Methyltransferase-like Protein 2b

DTO Classes

Protein / Enzyme / Transferase / Methyltransferase / Methyltransferase-like Protein 2b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.52   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 127   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.52   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0