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Tbio
LLGL2
Lethal(2) giant larvae protein homolog 2

Protein Summary
Description
Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity. The lethal (2) giant larvae protein of Drosophila plays a role in asymmetric cell division, epithelial cell polarity, and cell migration. This human gene encodes a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000167462
  • ENSP00000167462
  • ENSG00000073350
  • ENST00000375227
  • ENSP00000364375
  • ENST00000392550
  • ENSP00000376333
  • ENST00000578363
  • ENSP00000464603

Symbol
  • HGL
  • LGL2
  • Hugl-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
histone modification site profile
0.79
PubMedID
0.71
transcription factor
0.7
disease perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.4   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 182   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.4   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
forced expiratory volume
1
1
1
43.3
heel bone mineral density
1
1
1
23.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
forced expiratory volume
1
43.3
heel bone mineral density
1
23.6
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (3)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Tight junction
KEGG
Hippo signaling pathway
KEGG
Human papillomavirus infection
Name
Explore in Pharos
Explore in Source
Tight junction
Hippo signaling pathway
Human papillomavirus infection
Gene Ontology Terms (13)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (83)
1 – 10 of 83
PARD6B
Tbio
Novelty: 0.08495161
p_int: 1
Score: 0.991
Data Source: BioPlex,STRINGDB
PRKCZ
Tchem
Family: Kinase
Novelty: 0.00201366
p_int: 0.999999997
p_ni: 3e-9
Score: 0.86
Data Source: BioPlex,STRINGDB
RAD18
Tbio
Family: Enzyme
Novelty: 0.00519213
p_int: 0.999999924
p_ni: 7.6e-8
Data Source: BioPlex
PARD6G
Tbio
Novelty: 0.23553331
p_int: 0.999999829
p_ni: 1.56e-7
p_wrong: 1.5e-8
Score: 0.941
Data Source: BioPlex,STRINGDB
BRWD3
Tbio
Family: Epigenetic
Novelty: 0.08846384
p_int: 0.99999967
p_ni: 1e-9
p_wrong: 3.29e-7
Score: 0.215
Data Source: BioPlex,STRINGDB
ZMYND8
Tbio
Family: Epigenetic
Novelty: 0.05352096
p_int: 0.999998388
p_ni: 0.000001612
Data Source: BioPlex
GSE1
Tdark
Novelty: 0.04331197
p_int: 0.999973276
p_ni: 0.000026724
p_wrong: 1e-9
Score: 0.351
Data Source: BioPlex,STRINGDB
PRKCI
Tchem
Family: Kinase
Novelty: 0.0076377
p_int: 0.999967739
p_ni: 0.000032261
Score: 0.993
Data Source: BioPlex,STRINGDB
DCAF1
Tbio
Novelty: 0.0170232
p_int: 0.999951315
p_ni: 0.000048685
Score: 0.544
Data Source: BioPlex,STRINGDB
ZNF592
Tbio
Novelty: 0.12109299
p_int: 0.999946464
p_ni: 0.00005352
p_wrong: 1.6e-8
Score: 0.196
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  13.40

PubMed score by year
PubTator Score  25.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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