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Tchem
SLC27A4
Long-chain fatty acid transport protein 4

Protein Summary
Description
Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (VLCFAs). Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones (By similarity). This gene encodes a member of a family of fatty acid transport proteins, which are involved in translocation of long-chain fatty acids cross the plasma membrane. This protein is expressed at high levels on the apical side of mature enterocytes in the small intestine, and appears to be the principal fatty acid transporter in enterocytes. Clinical studies suggest this gene as a candidate gene for the insulin resistance syndrome. Mutations in this g ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300456
  • ENSP00000300456
  • ENSG00000167114
  • ENST00000372870
  • ENSP00000361961

Symbol
  • ACSVL4
  • FATP4
  • IPS
  • FATP4
  • ACSVL4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
cellular component
0.81
protein domain
0.73
transcription factor perturbation
0.68
cell line
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.29   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.29   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 14
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (14)
CHEMBL209855
Rendered image for CHEMBL209855
CHEMBL211612
Rendered image for CHEMBL211612
CHEMBL426323
Rendered image for CHEMBL426323
CHEMBL211941
Rendered image for CHEMBL211941
CHEMBL211864
Rendered image for CHEMBL211864
CHEMBL211117
Rendered image for CHEMBL211117
CHEMBL437303
Rendered image for CHEMBL437303
CHEMBL212149
Rendered image for CHEMBL212149
CHEMBL378290
Rendered image for CHEMBL378290
CHEMBL211772
Rendered image for CHEMBL211772
Protein-Protein Interactions (60)
LRBA
Tbio
Novelty:  0.00093369
p_int:  0.99221591
p_ni:  0.00778409
Data Source:  BioPlex
RDH13
Tbio
Family:  Enzyme
Novelty:  0.20184998
p_int:  0.974596487
p_ni:  0.02535168
p_wrong:  0.000051834
Data Source:  BioPlex
FSD2
Tbio
Novelty:  0.1302271
p_int:  0.930818145
p_ni:  0.069181855
Data Source:  BioPlex
SLC27A1
Tchem
Family:  Transporter
Novelty:  0.0065328
Score:  0.812
Data Source:  STRINGDB
NIPAL4
Tbio
Novelty:  0.05110099
Score:  0.708
Data Source:  STRINGDB
CD36
Tbio
Novelty:  0.00140825
Score:  0.69
Data Source:  STRINGDB
ACSL1
Tbio
Family:  Enzyme
Novelty:  0.00336161
Score:  0.675
Data Source:  STRINGDB
ACSL5
Tchem
Family:  Enzyme
Novelty:  0.00850919
Score:  0.671
Data Source:  STRINGDB
RPL23
Tbio
Novelty:  0.02741113
Score:  0.623
Data Source:  STRINGDB
FABP1
Tchem
Novelty:  0.00192691
Score:  0.614
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS) (R-HSA-5619108)

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Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
SLC transporter disorders
Reactome
SLC-mediated transmembrane transport
Name
Explore in Pharos
Explore in Source
Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS)
Disease
Disorders of transmembrane transporters
SLC transporter disorders
SLC-mediated transmembrane transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
5
3
5
75.5
body height
1
1
1
44.2
pulse pressure measurement
1
1
1
9.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
5
75.5
body height
1
44.2
pulse pressure measurement
1
9.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 27 member 4
VGNC:8931
740977
Macaque
solute carrier family 27 member 4
722620
Mouse
MGI:1347347
26569
Rat
RGD:1307383
311839
Dog
solute carrier family 27 member 4
VGNC:46332
491317
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 27 member 4
Macaque
solute carrier family 27 member 4
Mouse
Rat
Dog
solute carrier family 27 member 4
Publication Statistics
PubMed Score 63.29
PubMed score by year
PubTator Score 45.25
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title