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Tdark
MRPL14
39S ribosomal protein L14, mitochondrial

Protein Summary
Description
Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation (Probable). This nuclear gene encodes a protein component of the 39S subunit of the mitochondrial ribosome. A pseudogene of this gene is found on chromosome 17. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372014
  • ENSP00000361084
  • ENSG00000180992

Symbol
  • MRPL32
  • RPML32
  • L14mt
  • L32mt
  • MRPL32
  • RMPL32
  • RPML32
  • MRP-L14
  • MRP-L32
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.76
transcription factor binding site profile
0.7
small molecule perturbation
0.68
transcription factor
0.67
histone modification site profile
0.65


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.5   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 109   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.5   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L14
VGNC:3490
462726
Mouse
MGI:1333864
68463
Rat
RGD:1306240
301250
Dog
mitochondrial ribosomal protein L14
VGNC:43379
474918
Horse
mitochondrial ribosomal protein L14
VGNC:20325
100067678
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L14
Mouse
Rat
Dog
mitochondrial ribosomal protein L14
Horse
mitochondrial ribosomal protein L14
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q6P1L8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (131)
1 – 10 of 131
MRPL18
Tbio
Novelty: 0.73438796
p_int: 0.949246493
p_ni: 0.050753507
Score: 0.987
Data Source: BioPlex,STRINGDB
MRPL10
Tbio
Novelty: 0.27087019
p_int: 0.90066832
p_ni: 0.09933168
Score: 0.979
Data Source: BioPlex,STRINGDB
MRPL50
Tdark
Novelty: 0.88879319
p_int: 0.89206363
p_ni: 0.10793637
Score: 0.995
Data Source: BioPlex,STRINGDB
MRPL41
Tbio
Novelty: 0.04024303
p_int: 0.854459147
p_ni: 0.145540853
Score: 0.997
Data Source: BioPlex,STRINGDB
MRPL30
Tdark
Novelty: 1.03623556
p_int: 0.850575352
p_ni: 0.149424648
Score: 0.993
Data Source: BioPlex,STRINGDB
MRPL39
Tbio
Novelty: 0.14346457
p_int: 0.814340526
p_ni: 0.185659474
Score: 0.985
Data Source: BioPlex,STRINGDB
MRPS30
Tbio
Novelty: 0.08115544
p_int: 0.796797432
p_ni: 0.203202568
Score: 0.995
Data Source: BioPlex,STRINGDB
MRPL47
Tbio
Novelty: 0.05648009
p_int: 0.779683771
p_ni: 0.220316229
Score: 0.996
Data Source: BioPlex,STRINGDB
MRPL53
Tdark
Novelty: 1.0076471
p_int: 0.757337625
p_ni: 0.242662375
Score: 0.987
Data Source: BioPlex,STRINGDB
MRPL19
Tbio
Novelty: 0.04235101
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  0.50

PubMed score by year
PubTator Score  0.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer