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Tdark
GTF2H2C
General transcription factor IIH subunit 2-like protein

Protein Classes
Protein Summary
Description
Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380729
  • ENSP00000370105
  • ENSG00000183474
  • ENST00000510979
  • ENSP00000422907
  • ENST00000619699
  • ENSP00000483148
  • ENSG00000274675
  • ENST00000621406
  • ENSP00000480471

Symbol
  • GTF2H2C_2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.68
cell line
0.48
small molecule perturbation
0.46
protein complex
0.45
microRNA
0.43


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.55   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.55   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
1
1
42.3
myeloid white cell count
1
1
1
10.1
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
42.3
myeloid white cell count
1
10.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1345669
23894
Rat
RGD:1310499
294693
Dog
general transcription factor IIH subunit 2
478089
Horse
general transcription factor IIH subunit 2
100073305
Cow
general transcription factor IIH, polypeptide 2, 44kDa
511829
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
general transcription factor IIH subunit 2
Horse
general transcription factor IIH subunit 2
Cow
general transcription factor IIH, polypeptide 2, 44kDa
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6P1K8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Nucleotide excision repair
KEGG
Basal transcription factors
KEGG
Viral carcinogenesis
Name
Explore in Pharos
Explore in Source
Nucleotide excision repair
Basal transcription factors
Viral carcinogenesis
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (71)
1 – 10 of 71
GTF2H1
Tbio
Novelty:  0.01736328
Score:  0.999
Data Source:  STRINGDB
GTF2H3
Tbio
Novelty:  0.08168167
Score:  0.997
Data Source:  STRINGDB
GTF2H4
Tbio
Novelty:  0.03140561
Score:  0.997
Data Source:  STRINGDB
ERCC3
Tbio
Family:  Enzyme
Novelty:  0.00978601
Score:  0.994
Data Source:  STRINGDB
GTF2H5
Tbio
Novelty:  0.03493285
Score:  0.978
Data Source:  STRINGDB
GTF2H2
Tbio
Novelty:  0.02761619
Score:  0.96
Data Source:  STRINGDB
ERCC2
Tchem
Family:  Enzyme
Novelty:  0.00240155
Score:  0.953
Data Source:  STRINGDB
MNAT1
Tbio
Family:  Enzyme
Novelty:  0.02484936
Score:  0.929
Data Source:  STRINGDB
CDK7
Tchem
Family:  Kinase
Novelty:  0.00322814
Score:  0.919
Data Source:  STRINGDB
GTF2E1
Tbio
Novelty:  0.39883299
Score:  0.785
Data Source:  STRINGDB
Publication Statistics
PubMed Score  0.55

PubMed score by year
PubTator Score  0.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer