Protein Summary
Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. P ...more
- ENST00000367435
- ENSP00000356405
- ENSG00000134371
- ENST00000650099
- ENSP00000498073
- C1orf28
- HRPT2
- HYX
- FIHP
- HPTJT
- HRPT1
- HRPT2
- C1orf28
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 1 | ||
biological process | 0.98 | ||
transcription factor perturbation | 0.91 | ||
kinase perturbation | 0.88 | ||
transcription factor binding site profile | 0.81 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 328.46 (req: < 5)
Gene RIFs: 92 (req: <= 3)
Antibodies: 248 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 328.46 (req: >= 5)
Gene RIFs: 92 (req: > 3)
Antibodies: 248 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 26
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (203)
LEO1
Family: Enzyme
Novelty: 0.00851903
p_int: 1
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CTR9
Family: Enzyme
Novelty: 0.04434964
p_int: 0.999999771
p_ni: 2.18e-7
p_wrong: 1.1e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
PAF1
Family: Enzyme
Novelty: 0.00200047
p_int: 0.999933011
p_ni: 0.000066989
Score: 0.999
Data Source: BioPlex,STRINGDB
TULP2
Family: TF
Novelty: 0.20144336
p_int: 0.974897962
p_ni: 0.025102038
Score: 0.81
Data Source: BioPlex,STRINGDB
ERMAP
Novelty: 0.04270359
p_int: 0.893406645
p_ni: 0.106593355
Score: 0.187
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (65)
Reactome (15)
WikiPathways (50)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | E3 ubiquitin ligases ubiquitinate target proteins | ||||
Reactome | Formation of RNA Pol II elongation complex | ||||
Reactome | Formation of the beta-catenin:TCF transactivating complex | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Hedgehog 'on' state | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
E3 ubiquitin ligases ubiquitinate target proteins | ||||
Formation of RNA Pol II elongation complex | ||||
Formation of the beta-catenin:TCF transactivating complex | ||||
Gene expression (Transcription) | ||||
Hedgehog 'on' state | ||||
Viral Interactions (0)
Gene Ontology Terms (31)
Functions (1)
Components (5)
Processes (25)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
lifestyle measurement | 1 | 1 | 1 | 31.4 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
lifestyle measurement | 1 | 31.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | cell division cycle 73 | VGNC:1213 | 745351 | |||||
Macaque | cell division cycle 73 | 712256 | ||||||
Mouse | MGI:2384876 | 214498 | ||||||
Rat | RGD:1311766 | 304832 | ||||||
Dog | cell division cycle 73 | VGNC:39011 | 478955 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | cell division cycle 73 | |||||
Macaque | cell division cycle 73 | |||||
Mouse | ||||||
Rat | ||||||
Dog | cell division cycle 73 | |||||
Publication Statistics
PubMed Score 328.46
PubMed score by year
PubTator Score 229.90
PubTator score by year
Related Publications
Text Mined References (120)
GeneRif Annotations (92)
Items per page:
0 of 0
PMID | Year | Title |
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