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Tbio
CDC73
Parafibromin

Protein Summary
Description
Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. P ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367435
  • ENSP00000356405
  • ENSG00000134371
  • ENST00000650099
  • ENSP00000498073

Symbol
  • C1orf28
  • HRPT2
  • HYX
  • FIHP
  • HPTJT
  • HRPT1
  • HRPT2
  • C1orf28
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
biological process
0.98
transcription factor perturbation
0.91
kinase perturbation
0.88
transcription factor binding site profile
0.81


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 322.73   (req: < 5)
Gene RIFs: 92   (req: <= 3)
Antibodies: 248   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 322.73   (req: >= 5)
Gene RIFs: 92   (req: > 3)
Antibodies: 248   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cell division cycle 73
VGNC:1213
745351
Macaque
cell division cycle 73
712256
Mouse
MGI:2384876
214498
Rat
RGD:1311766
304832
Dog
cell division cycle 73
VGNC:39011
478955
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cell division cycle 73
Macaque
cell division cycle 73
Mouse
Rat
Dog
cell division cycle 73
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (65)
E3 ubiquitin ligases ubiquitinate target proteins (R-HSA-8866654)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
E3 ubiquitin ligases ubiquitinate target proteins
Reactome
Formation of RNA Pol II elongation complex
Reactome
Formation of the beta-catenin:TCF transactivating complex
Reactome
Gene expression (Transcription)
Reactome
Hedgehog 'on' state
Name
Explore in Pharos
Explore in Source
E3 ubiquitin ligases ubiquitinate target proteins
Formation of RNA Pol II elongation complex
Formation of the beta-catenin:TCF transactivating complex
Gene expression (Transcription)
Hedgehog 'on' state
Gene Ontology Terms (31)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (203)
1 – 10 of 203
LEO1
Tbio
Family: Enzyme
Novelty: 0.00851903
p_int: 1
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CTR9
Tbio
Family: Enzyme
Novelty: 0.04434964
p_int: 0.999999771
p_ni: 2.18e-7
p_wrong: 1.1e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
PAF1
Tbio
Family: Enzyme
Novelty: 0.00200047
p_int: 0.999933011
p_ni: 0.000066989
Score: 0.999
Data Source: BioPlex,STRINGDB
TULP2
Tdark
Family: TF
Novelty: 0.20144336
p_int: 0.974897962
p_ni: 0.025102038
Score: 0.81
Data Source: BioPlex,STRINGDB
ERMAP
Tbio
Novelty: 0.04270359
p_int: 0.893406645
p_ni: 0.106593355
Score: 0.187
Data Source: BioPlex,STRINGDB
WDR61
Tbio
Novelty: 0.01405991
Score: 0.999
Data Source: STRINGDB
RTF1
Tbio
Family: Enzyme
Novelty: 0.02255644
Score: 0.999
Data Source: STRINGDB
SUPT16H
Tbio
Family: Enzyme
Novelty: 0.01026868
Score: 0.993
Data Source: STRINGDB
SUPT5H
Tbio
Novelty: 0.00775042
Score: 0.992
Data Source: STRINGDB
SSRP1
Tbio
Family: TF
Novelty: 0.0143993
Score: 0.992
Data Source: STRINGDB
Publication Statistics
PubMed Score  322.73

PubMed score by year
PubTator Score  229.9

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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