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Tbio
CDC73
Parafibromin

Protein Summary
Description
Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. P ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367435
  • ENSP00000356405
  • ENSG00000134371
  • ENST00000650099
  • ENSP00000498073

Symbol
  • C1orf28
  • HRPT2
  • HYX
  • FIHP
  • HPTJT
  • HRPT1
  • HRPT2
  • C1orf28
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
biological process
0.98
transcription factor perturbation
0.91
kinase perturbation
0.88
transcription factor binding site profile
0.81


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 328.46   (req: < 5)
Gene RIFs: 92   (req: <= 3)
Antibodies: 248   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 328.46   (req: >= 5)
Gene RIFs: 92   (req: > 3)
Antibodies: 248   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (203)
LEO1
Tbio
Family:  Enzyme
Novelty:  0.00851903
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
CTR9
Tbio
Family:  Enzyme
Novelty:  0.04434964
p_int:  0.999999771
p_ni:  2.18e-7
p_wrong:  1.1e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
PAF1
Tbio
Family:  Enzyme
Novelty:  0.00200047
p_int:  0.999933011
p_ni:  0.000066989
Score:  0.999
Data Source:  BioPlex,STRINGDB
TULP2
Tdark
Family:  TF
Novelty:  0.20144336
p_int:  0.974897962
p_ni:  0.025102038
Score:  0.81
Data Source:  BioPlex,STRINGDB
ERMAP
Tbio
Novelty:  0.04270359
p_int:  0.893406645
p_ni:  0.106593355
Score:  0.187
Data Source:  BioPlex,STRINGDB
WDR61
Tbio
Novelty:  0.01405991
Score:  0.999
Data Source:  STRINGDB
RTF1
Tbio
Family:  Enzyme
Novelty:  0.02255644
Score:  0.999
Data Source:  STRINGDB
SUPT16H
Tbio
Family:  Enzyme
Novelty:  0.01026868
Score:  0.993
Data Source:  STRINGDB
SUPT5H
Tbio
Novelty:  0.00775042
Score:  0.992
Data Source:  STRINGDB
SSRP1
Tbio
Family:  TF
Novelty:  0.0143993
Score:  0.992
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (65)
E3 ubiquitin ligases ubiquitinate target proteins (R-HSA-8866654)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
E3 ubiquitin ligases ubiquitinate target proteins
Reactome
Formation of RNA Pol II elongation complex
Reactome
Formation of the beta-catenin:TCF transactivating complex
Reactome
Gene expression (Transcription)
Reactome
Hedgehog 'on' state
Name
Explore in Pharos
Explore in Source
E3 ubiquitin ligases ubiquitinate target proteins
Formation of RNA Pol II elongation complex
Formation of the beta-catenin:TCF transactivating complex
Gene expression (Transcription)
Hedgehog 'on' state
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lifestyle measurement
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lifestyle measurement
1
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cell division cycle 73
VGNC:1213
745351
Macaque
cell division cycle 73
712256
Mouse
MGI:2384876
214498
Rat
RGD:1311766
304832
Dog
cell division cycle 73
VGNC:39011
478955
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cell division cycle 73
Macaque
cell division cycle 73
Mouse
Rat
Dog
cell division cycle 73
Publication Statistics
PubMed Score 328.46
PubMed score by year
PubTator Score 229.90
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title