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Tchem
ERAP2
Endoplasmic reticulum aminopeptidase 2

Protein Summary
Description
Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys. This gene encodes a zinc metalloaminopeptidase of the M1 protease family that resides in the endoplasmic reticulum and functions in N-terminal trimming antigenic epitopes for presentation by major histocompatibility complex (MHC) class I molecules. Certain mutations in this gene are associated with the inflammatory arthritis syndrome ankylosing spondylitis and pre-eclampsia. This gene is located adjacent to a closely related aminopeptidase gene on chromosome 5. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379904
  • ENSP00000369235
  • ENSG00000164308
  • ENST00000437043
  • ENSP00000400376
  • ENST00000510309
  • ENSP00000425758
  • ENST00000513084
  • ENSP00000421849

Symbol
  • LRAP
  • LRAP
  • L-RAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.59
gene perturbation
0.57
virus perturbation
0.55
biological term
0.51
small molecule perturbation
0.51


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.65   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 111   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.65   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (16)
1 – 10 of 16
CHEMBL327844
chemical structure image
CHEMBL3416733
chemical structure image
CHEMBL3806197
chemical structure image
CHEMBL3355101
chemical structure image
CHEMBL3355104
chemical structure image
compound 17 [PMID: 23916253]
chemical structure image
CHEMBL3416696
chemical structure image
CHEMBL3416697
chemical structure image
CHEMBL3416726
chemical structure image
CHEMBL3806247
chemical structure image
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.1
83.3
1
1
0
1.2
74.9
2
1
0
1.1
70.2
1
1
0
1.1
40.8
1
1
0
1.1
33.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
83.3
0
1.2
74.9
0
1.1
70.2
0
1.1
40.8
0
1.1
33.6
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
endoplasmic reticulum aminopeptidase 2
VGNC:3979
461959
Macaque
endoplasmic reticulum aminopeptidase 2
700118
Dog
endoplasmic reticulum aminopeptidase 2
VGNC:40434
100856345
Horse
endoplasmic reticulum aminopeptidase 2
VGNC:17647
100073223
Cow
endoplasmic reticulum aminopeptidase 2
VGNC:28561
513572
Species
Name
OMA
EggNOG
Inparanoid
Chimp
endoplasmic reticulum aminopeptidase 2
Macaque
endoplasmic reticulum aminopeptidase 2
Dog
endoplasmic reticulum aminopeptidase 2
Horse
endoplasmic reticulum aminopeptidase 2
Cow
endoplasmic reticulum aminopeptidase 2
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Class I MHC mediated antigen processing & presentation
Immune System
Gene Ontology Terms (16)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HGNC
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (61)
1 – 10 of 61
TPP2
Tchem
Family: Enzyme
Novelty: 0.00803674
Score: 0.769
Data Source: STRINGDB
XPNPEP1
Tchem
Family: Enzyme
Novelty: 0.00345088
Score: 0.65
Data Source: STRINGDB
XPNPEP3
Tbio
Family: Enzyme
Novelty: 0.02209842
Score: 0.647
Data Source: STRINGDB
XPNPEP2
Tchem
Family: Enzyme
Novelty: 0.01453123
Score: 0.647
Data Source: STRINGDB
ZMPSTE24
Tbio
Family: Enzyme
Novelty: 0.0027993
Score: 0.627
Data Source: STRINGDB
AMELX
Tbio
Novelty: 0.00063284
Score: 0.59
Data Source: STRINGDB
CAST
Tbio
Novelty: 0.00099404
Score: 0.577
Data Source: STRINGDB
TAPBP
Tbio
Novelty: 0.00328098
Score: 0.569
Data Source: STRINGDB
TAPBPL
Tbio
Novelty: 0.06343547
Score: 0.554
Data Source: STRINGDB
TREH
Tchem
Family: Enzyme
Novelty: 0.00462386
Score: 0.554
Data Source: STRINGDB
Publication Statistics
PubMed Score  96.65

PubMed score by year
PubTator Score  63.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer