Tchem ERAP2 Endoplasmic reticulum aminopeptidase 2

Protein Summary

Description

Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys. This gene encodes a zinc metalloaminopeptidase of the M1 protease family that resides in the endoplasmic reticulum and functions in N-terminal trimming antigenic epitopes for presentation by major histocompatibility complex (MHC) class I molecules. Certain mutations in this gene are associated with the inflammatory arthritis syndrome ankylosing spondylitis and pre-eclampsia. This gene is located adjacent to a closely related aminopeptidase gene on chromosome 5. [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• Q6P179
• Q7Z5K1
• Q8TD32
• Q8WVJ4
• Q9HBX2

Gene Name

• ERAP2

Ensembl ID

• ENST00000379904
• ENSP00000369235
• ENSG00000164308
• ENST00000437043
• ENSP00000400376
• ENST00000510309
• ENSP00000425758
• ENST00000513084
• ENSP00000421849

Symbol

• LRAP
• LRAP
• L-RAP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.59
gene perturbation	0.57
virus perturbation	0.55
biological term	0.51
small molecule perturbation	0.51

Protein Classes

PANTHER Classes

Protein / ... / Metalloprotease / Endoplasmic Reticulum Aminopeptidase 2

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Endoplasmic Reticulum Aminopeptidase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.8   (req: < 5)

Gene RIFs: 72   (req: <= 3)

Antibodies: 111   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.8   (req: >= 5)

Gene RIFs: 72   (req: > 3)

Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 44

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0