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Tdark
MRPL54
39S ribosomal protein L54, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330133
  • ENSP00000331849
  • ENSG00000183617

Symbol
  • L54mt
  • MRP-L54
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.79
cell type or tissue
0.74
transcription factor binding site profile
0.7
histone modification site profile
0.66
cellular component
0.57


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.56   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 157   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.56   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L54
VGNC:2311
736047
Mouse
MGI:1913297
66047
Rat
RGD:1305694
299628
Dog
mitochondrial ribosomal protein L54
VGNC:43406
485052
Cow
mitochondrial ribosomal protein L54
VGNC:31649
511926
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L54
Mouse
Rat
Dog
mitochondrial ribosomal protein L54
Cow
mitochondrial ribosomal protein L54
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q6P161-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (143)
1 – 10 of 143
MRPL41
Tbio
Novelty: 0.04024303
Score: 0.997
Data Source: STRINGDB
MRPL27
Tbio
Novelty: 0.15636105
Score: 0.997
Data Source: STRINGDB
MRPL17
Tdark
Novelty: 1.20541719
Score: 0.997
Data Source: STRINGDB
MRPL20
Tdark
Novelty: 0.91178993
Score: 0.996
Data Source: STRINGDB
MRPL47
Tbio
Novelty: 0.05648009
Score: 0.995
Data Source: STRINGDB
MRPS6
Tbio
Novelty: 0.15569626
Score: 0.995
Data Source: STRINGDB
MRPS23
Tdark
Novelty: 0.3140597
Score: 0.995
Data Source: STRINGDB
MRPS12
Tbio
Novelty: 0.15394123
Score: 0.995
Data Source: STRINGDB
MRPS18A
Tdark
Novelty: 0.26321707
Score: 0.995
Data Source: STRINGDB
MRPL40
Tbio
Novelty: 0.09916967
Score: 0.994
Data Source: STRINGDB
Publication Statistics
PubMed Score  0.56

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer