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Tbio
MIS18BP1
Mis18-binding protein 1

Protein Summary
Description
Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310806
  • ENSP00000309790
  • ENSG00000129534

Symbol
  • C14orf106
  • KIAA1903
  • KNL2
  • M18BP1
  • KNL2
  • M18BP1
  • C14orf106
  • HSA242977
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.88
transcription factor perturbation
0.8
histone modification site profile
0.78
gene perturbation
0.7
cell type or tissue
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.75   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 56   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.75   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 56   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Chromosome Maintenance
Reactome
Deposition of new CENPA-containing nucleosomes at the centromere
Reactome
Nucleosome assembly
Name
Explore in Pharos
Explore in Source
Cell Cycle
Chromosome Maintenance
Deposition of new CENPA-containing nucleosomes at the centromere
Nucleosome assembly
Protein-Protein Interactions (152)
1 – 10 of 152
MIS18A
Tbio
Novelty: 0.00785124
p_int: 0.999999354
p_ni: 6.45e-7
p_wrong: 1e-9
Score: 0.988
Data Source: BioPlex,Reactome,STRINGDB
NCAPH2
Tbio
Novelty: 0.16162826
p_int: 0.999993982
p_ni: 0.000006018
Score: 0.516
Data Source: BioPlex,STRINGDB
GOPC
Tbio
Novelty: 0.0164207
p_int: 0.999993598
p_ni: 0.000006402
Data Source: BioPlex
CAV3
Tbio
Novelty: 0.00250765
p_int: 0.999983346
p_ni: 0.000016645
p_wrong: 1e-8
Score: 0.663
Data Source: BioPlex,STRINGDB
EIF2B5
Tbio
Novelty: 0.01114599
p_int: 0.999968409
p_ni: 0.000030905
p_wrong: 6.86e-7
Data Source: BioPlex
IKZF5
Tbio
Family: TF
Novelty: 1
p_int: 0.999918499
p_ni: 0.000081495
p_wrong: 6e-9
Score: 0.158
Data Source: BioPlex,STRINGDB
CACNG5
Tdark
Family: IC
Novelty: 0.81553398
p_int: 0.999883173
p_ni: 0.000116823
p_wrong: 5e-9
Data Source: BioPlex
OIP5
Tbio
Novelty: 0.04164588
p_int: 0.999860708
p_ni: 0.000139279
p_wrong: 1.3e-8
Score: 0.995
Data Source: BioPlex,Reactome,STRINGDB
LZTS2
Tbio
Novelty: 0.12012012
p_int: 0.999512997
p_ni: 0.000256863
p_wrong: 0.00023014
Score: 0.333
Data Source: BioPlex,STRINGDB
HJURP
Tbio
Novelty: 0.0305226
Score: 0.997
Data Source: STRINGDB
Publication Statistics
PubMed Score  12.75

PubMed score by year
PubTator Score  7.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer