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Tbio
MIS18BP1
Mis18-binding protein 1

Protein Summary
Description
Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310806
  • ENSP00000309790
  • ENSG00000129534

Symbol
  • C14orf106
  • KIAA1903
  • KNL2
  • M18BP1
  • KNL2
  • M18BP1
  • C14orf106
  • HSA242977
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.88
transcription factor perturbation
0.8
histone modification site profile
0.78
gene perturbation
0.7
cell type or tissue
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.2   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 56   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.2   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 56   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (152)
MIS18A
Tbio
Novelty:  0.08143008
p_int:  0.999999354
p_ni:  6.45e-7
p_wrong:  1e-9
Score:  0.988
Data Source:  BioPlex,Reactome,STRINGDB
NCAPH2
Tbio
Novelty:  0.12134933
p_int:  0.999993982
p_ni:  0.000006018
Score:  0.516
Data Source:  BioPlex,STRINGDB
GOPC
Tchem
Novelty:  0.01110168
p_int:  0.999993598
p_ni:  0.000006402
Data Source:  BioPlex
CAV3
Tbio
Novelty:  0.00190092
p_int:  0.999983346
p_ni:  0.000016645
p_wrong:  1e-8
Score:  0.663
Data Source:  BioPlex,STRINGDB
EIF2B5
Tbio
Novelty:  0.0102209
p_int:  0.999968409
p_ni:  0.000030905
p_wrong:  6.86e-7
Data Source:  BioPlex
IKZF5
Tbio
Family:  TF
Novelty:  0.36596327
p_int:  0.999918499
p_ni:  0.000081495
p_wrong:  6e-9
Score:  0.158
Data Source:  BioPlex,STRINGDB
CACNG5
Tdark
Family:  IC
Novelty:  0.52705448
p_int:  0.999883173
p_ni:  0.000116823
p_wrong:  5e-9
Data Source:  BioPlex
OIP5
Tbio
Novelty:  0.02546471
p_int:  0.999860708
p_ni:  0.000139279
p_wrong:  1.3e-8
Score:  0.995
Data Source:  BioPlex,Reactome,STRINGDB
LZTS2
Tbio
Novelty:  0.09515452
p_int:  0.999512997
p_ni:  0.000256863
p_wrong:  0.00023014
Score:  0.333
Data Source:  BioPlex,STRINGDB
HJURP
Tbio
Novelty:  0.02317704
Score:  0.997
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Cell Cycle (R-HSA-1640170)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Chromosome Maintenance
Reactome
Deposition of new CENPA-containing nucleosomes at the centromere
Reactome
Nucleosome assembly
Name
Explore in Pharos
Explore in Source
Cell Cycle
Chromosome Maintenance
Deposition of new CENPA-containing nucleosomes at the centromere
Nucleosome assembly
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
2
1
2
58.5
self reported educational attainment
1
1
1
4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
2
58.5
self reported educational attainment
1
4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MIS18 binding protein 1
VGNC:3381
467444
Macaque
MIS18 binding protein 1
702644
Mouse
MGI:2145099
217653
Rat
RGD:1594757
689296
Dog
MIS18 binding protein 1
VGNC:43245
100682620
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MIS18 binding protein 1
Macaque
MIS18 binding protein 1
Mouse
Rat
Dog
MIS18 binding protein 1
Publication Statistics
PubMed Score 27.20
PubMed score by year
PubTator Score 7.93
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title