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Tdark
FBXL22
F-box and leucine-rich protein 22

Protein Summary
Description
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes ubiquitination of sarcomeric proteins alpha-actinin-2 (ACTN2) and filamin-C (FLNC). This gene encodes a member of the F-box protein family. This F-box protein interacts with S-phase kinase-associated protein 1A and cullin in order to form SCF complexes which function as ubiquitin ligases.[provided by RefSeq, Sep 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360587
  • ENSP00000353794
  • ENSG00000197361

Symbol
  • Fbl22
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.59
cell type or tissue
0.56
transcription factor
0.52
cell line
0.45
microRNA
0.38


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.89   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 55   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.89   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
1
1
9.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
9.3
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
F-box and leucine rich repeat protein 22 [Source:HGNC Symbol;Acc:HGNC:27537]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
F-box and leucine rich repeat protein 22 [Source:HGNC Symbol;Acc:HGNC:27537]
Pathways (8)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Protein-Protein Interactions (321)
1 – 10 of 321
CLTCL1
Tbio
Novelty: 0.05667807
p_int: 0.997729409
p_ni: 0.002270591
Data Source: BioPlex
EEF1A2
Tchem
Novelty: 0.001472
p_int: 0.990615894
p_ni: 0.009384106
Data Source: BioPlex
SKP1
Tbio
Family: Enzyme
Novelty: 0.00149739
p_int: 0.958285848
p_ni: 0.041714152
Score: 0.98
Data Source: BioPlex,STRINGDB
GNAO1
Tbio
Novelty: 0.00315097
p_int: 0.931404592
p_ni: 0.068595408
Data Source: BioPlex
NCS1
Tbio
Novelty: 0.0051468
p_int: 0.927242134
p_ni: 0.0727573
p_wrong: 5.66e-7
Data Source: BioPlex
SRC
Tclin
Family: Kinase
Novelty: 0.00008479
p_int: 0.912743701
p_ni: 0.086371244
p_wrong: 0.000885054
Data Source: BioPlex
BLK
Tchem
Family: Kinase
Novelty: 0.00480349
p_int: 0.812824331
p_ni: 0.185577217
p_wrong: 0.001598452
Data Source: BioPlex
USP22
Tbio
Family: Enzyme
Novelty: 0.01416662
p_int: 0.810509367
p_ni: 0.171974431
p_wrong: 0.017516202
Data Source: BioPlex
ULBP2
Tbio
Novelty: 0.01604318
p_int: 0.772594353
p_ni: 0.227401794
p_wrong: 0.000003853
Data Source: BioPlex
CUL1
Tbio
Novelty: 0.00244476
Score: 0.977
Data Source: STRINGDB
Publication Statistics
PubMed Score  1.89

PubMed score by year
PubTator Score  1.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer