Tbio ZCCHC8 Zinc finger CCHC domain-containing protein 8

Protein Summary

Description

Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non-coding short-lived RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (PubMed:27871484). May be involved in pre-mRNA splicing (Probable). This gene encodes a scaffold protein which serves as an assessory factor to the nuclear RNA exosome complex. The encoded protein forms a trimeric human nuclear exosome targeting (NEXT) complex, together with hMTR4 and the RNA-binding factor RBM7 which promotes the exosomal degradation of non-coding promoter-upstream transcripts, enhancer RNAs and 3'-extended products of histone- and small nuclear RNA transcription. This complex is also thought to recruit the exosome to degrade intronic RNAs via its interaction with both the exosome and the spliceosome. It contains both an N-terminal zinc-knuckle domain and a C-terminal proline-rich domain. [provided by RefSeq, Apr 2017]

Uniprot Accession IDs

• Q6NZY4
• Q7L2P6
• Q8N2K5
• Q96SK7
• Q9NSS2
• Q9NSS3

Gene Name

• ZCCHC8

Ensembl ID

• ENST00000536306
• ENSP00000441423
• ENSG00000033030
• ENST00000543897
• ENSP00000438993
• ENST00000633063
• ENSP00000488055

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.96
transcription factor binding site profile	0.92
histone modification site profile	0.7
cell line	0.65
interacting protein	0.61

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Zinc Finger Cchc Domain-containing Protein 8

DTO Classes

Protein / Nucleic Acid Binding / Zinc Finger Cchc Domain-containing Protein 8

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.15   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 104   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.15   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0