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Tbio
CAVIN1
Caveolae-associated protein 1

Protein Summary
Description
Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues (PubMed:18056712, PubMed:18191225, PubMed:19726876). Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template (By similarity). This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcri ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357037
  • ENSP00000349541
  • ENSG00000177469

Symbol
  • PTRF
  • CGL4
  • PTRF
  • CAVIN
  • FKSG13
  • cavin-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 154.69   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 203   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 154.69   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (120)
MAGI3
Tbio
Family:  Enzyme
Novelty:  0.03968945
p_int:  0.999999993
p_ni:  6e-9
p_wrong:  1e-9
Score:  0.173
Data Source:  BioPlex,STRINGDB
UBE2O
Tbio
Novelty:  0.07084123
p_int:  0.999998457
p_ni:  0.000001543
Data Source:  BioPlex
TSKS
Tbio
Family:  Enzyme
Novelty:  0.0886446
p_int:  0.999993839
p_ni:  0.000006161
Score:  0.239
Data Source:  BioPlex,STRINGDB
MB21D2
Tdark
Novelty:  0.48908631
p_int:  0.999993551
p_ni:  0.000001253
p_wrong:  0.000005196
Score:  0.228
Data Source:  BioPlex,STRINGDB
EXOC1
Tbio
Novelty:  0.01073858
p_int:  0.999989758
p_ni:  0.000010242
Data Source:  BioPlex
MAD1L1
Tbio
Novelty:  0.03550138
p_int:  0.999934807
p_ni:  0.000065193
Score:  0.239
Data Source:  BioPlex,STRINGDB
NUP62
Tbio
Novelty:  0.01432724
p_int:  0.999647142
p_ni:  0.000352858
Data Source:  BioPlex
ZBTB1
Tbio
Family:  TF
Novelty:  0.33667235
p_int:  0.999475904
p_ni:  0.000342377
p_wrong:  0.00018172
Data Source:  BioPlex
ZNF622
Tbio
Novelty:  0.26258288
p_int:  0.999362567
p_ni:  0.000130849
p_wrong:  0.000506584
Score:  0.189
Data Source:  BioPlex,STRINGDB
FAM9A
Tdark
Novelty:  0.72563725
p_int:  0.998712775
p_ni:  0.001287225
Score:  0.209
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
General transcription by RNA polymerase I
PathwayCommons: netpath
EGFR1
Name
Explore in Pharos
Explore in Source
General transcription by RNA polymerase I
EGFR1
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
5
0
1.1
94.1
4
4
0
1.2
85.2
waist-hip ratio
1
4
4
74.8
1
1
0
1.1
74.4
BMI-adjusted waist-hip ratio
1
4
4
72.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
94.1
0
1.2
85.2
waist-hip ratio
4
74.8
0
1.1
74.4
BMI-adjusted waist-hip ratio
4
72.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
caveolae associated protein 1
VGNC:48941
454684
Mouse
MGI:1277968
19285
Rat
RGD:1307685
287710
Dog
caveolae associated protein 1
VGNC:38754
100855435
Horse
caveolae associated protein 1
VGNC:16088
100066120
Species
Name
OMA
EggNOG
Inparanoid
Chimp
caveolae associated protein 1
Mouse
Rat
Dog
caveolae associated protein 1
Horse
caveolae associated protein 1
Publication Statistics
PubMed Score 154.69
PubMed score by year
PubTator Score 82.02
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title