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Tbio
FAAP20
Fanconi anemia core complex-associated protein 20

Protein Summary
Description
Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378543
  • ENSP00000367804
  • ENSG00000162585
  • ENST00000378546
  • ENSP00000367808
  • ENST00000400918
  • ENSP00000383709
  • ENST00000414253
  • ENSP00000410450

Symbol
  • C1orf86
  • FP7162
  • C1orf86
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.47   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 52   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.47   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 52   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (47)
FANCG
Tbio
Novelty:  0.00908902
p_int:  0.999999545
p_ni:  4.32e-7
p_wrong:  2.3e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
FANCA
Tbio
Novelty:  0.00324947
p_int:  0.999991349
p_ni:  0.00000865
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
NT5C
Tbio
Family:  Enzyme
Novelty:  0.00686933
p_int:  0.899219992
p_ni:  0.100780006
p_wrong:  1e-9
Score:  0.269
Data Source:  BioPlex,STRINGDB
FANCL
Tbio
Family:  Enzyme
Novelty:  0.00274467
Score:  0.999
Data Source:  STRINGDB
FANCF
Tchem
Novelty:  0.01745498
Score:  0.999
Data Source:  STRINGDB
UBC
Tbio
Novelty:  0.00204643
Score:  0.999
Data Source:  STRINGDB
FANCE
Tbio
Novelty:  0.04484113
Score:  0.999
Data Source:  STRINGDB
FANCB
Tbio
Novelty:  0.00268111
Score:  0.999
Data Source:  STRINGDB
FANCC
Tbio
Novelty:  0.00546581
Score:  0.999
Data Source:  STRINGDB
FANCM
Tbio
Novelty:  0.01122278
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
2
2
83.7
platelet crit
2
2
2
80.4
serum alanine aminotransferase measurement
2
2
1
6
76.2
electrocardiography
1
1
88
68.6
low density lipoprotein cholesterol measurement
1
1
1
52.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
83.7
platelet crit
2
80.4
serum alanine aminotransferase measurement
1
6
76.2
electrocardiography
88
68.6
low density lipoprotein cholesterol measurement
1
52.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Fanconi anemia core complex associated protein 20
VGNC:54248
457213
Mouse
MGI:1914763
67513
Rat
RGD:1308923
362678
Cow
Fanconi anemia core complex associated protein 20
508039
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Fanconi anemia core complex associated protein 20
Mouse
Rat
Cow
Fanconi anemia core complex associated protein 20
Publication Statistics
PubMed Score 8.47
PubMed score by year
PubTator Score 5.18
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title