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Tdark
KANK3
KN motif and ankyrin repeat domain-containing protein 3

Protein Summary
Description
May be involved in the control of cytoskeleton formation by regulating actin polymerization.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330915
  • ENSP00000328923
  • ENSG00000186994
  • ENST00000593649
  • ENSP00000470728

Symbol
  • ANKRD47
  • ANKRD47
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.83
tissue sample
0.74
gene perturbation
0.65
histone modification site profile
0.65
co-expressed gene
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.08   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 53   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.08   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (28)
CCDC73
Tdark
Novelty:  0.80048057
Score:  0.742
Data Source:  STRINGDB
RPS28
Tbio
Novelty:  0.03303065
Score:  0.643
Data Source:  STRINGDB
PHLDA3
Tbio
Novelty:  0.07016635
Score:  0.593
Data Source:  STRINGDB
PRRG3
Tbio
Novelty:  0.19255708
Score:  0.589
Data Source:  STRINGDB
ANGPTL4
Tbio
Novelty:  0.00237867
Score:  0.571
Data Source:  STRINGDB
CRIP2
Tbio
Novelty:  0.02211769
Score:  0.565
Data Source:  STRINGDB
RFX7
Tdark
Family:  TF
Novelty:  0.15609316
Score:  0.552
Data Source:  STRINGDB
BPTF
Tchem
Family:  Epigenetic
Novelty:  0.00826037
Score:  0.543
Data Source:  STRINGDB
KCNV2
Tclin
Family:  IC
Novelty:  0.02600406
Score:  0.54
Data Source:  STRINGDB
ABHD4
Tbio
Family:  Enzyme
Novelty:  0.1068785
Score:  0.537
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
13
8
20
4
99.5
triglyceride measurement
9
3
12
98
apolipoprotein A 1 measurement
2
3
4
97.1
red blood cell distribution width
2
2
3
90.7
reticulocyte measurement
3
5
7
85.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
20
4
99.5
triglyceride measurement
12
98
apolipoprotein A 1 measurement
4
97.1
red blood cell distribution width
3
90.7
reticulocyte measurement
7
85.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
KN motif and ankyrin repeat domains 3
VGNC:2347
456437
Macaque
KN motif and ankyrin repeat domains 3 [Source:HGNC Symbol;Acc:HGNC:24796]
Mouse
MGI:1098615
80880
Rat
RGD:1308853
366848
Dog
KN motif and ankyrin repeat domains 3
VGNC:42202
476723
Species
Name
OMA
EggNOG
Inparanoid
Chimp
KN motif and ankyrin repeat domains 3
Macaque
KN motif and ankyrin repeat domains 3 [Source:HGNC Symbol;Acc:HGNC:24796]
Mouse
Rat
Dog
KN motif and ankyrin repeat domains 3
Publication Statistics
PubMed Score 2.08
PubMed score by year
PubTator Score 1.56
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title