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Tbio
TAPT1
Transmembrane anterior posterior transformation protein 1 homolog

Protein Summary
Description
Plays a role in primary cilia formation (PubMed:26365339). May act as a downstream effector of HOXC8 possibly by transducing or transmitting extracellular information required for axial skeletal patterning during development (By similarity). May be involved in cartilage and bone development (By similarity). May play a role in the differentiation of cranial neural crest cells (By similarity). (Microbial infection) In case of infection, may act as a fusion receptor for cytomegalovirus (HCMV) strain AD169. This gene encodes a highly conserved protein that localizes to the centrosome and/or ciliary basal body. Mutations in this gene disrupt Golgi morphology and trafficking and normal primary cilium formation and these mutations are congenitally manifested by severe undermineralization of the intra-uterine skeleton. A mutation in the mouse ortholog of this gene results in homeotic, posterior-to-anterior transformations of the axial skeleton which are similar to the phenotype of mouse homeob ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000405303
  • ENSP00000385347
  • ENSG00000169762

Symbol
  • CMVFR
  • CMVFR
  • OCLSBG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
transcription factor perturbation
0.74
microRNA
0.63
disease perturbation
0.56
histone modification site profile
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.03   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 74   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.03   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 74   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
33.1
cognitive function measurement
1
1
1
5.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
33.1
cognitive function measurement
1
5.5
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane anterior posterior transformation 1
VGNC:734
461128
Macaque
transmembrane anterior posterior transformation 1
714712
Mouse
MGI:2683537
231225
Rat
RGD:1309656
305386
Dog
transmembrane anterior posterior transformation 1
VGNC:53245
488815
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane anterior posterior transformation 1
Macaque
transmembrane anterior posterior transformation 1
Mouse
Rat
Dog
transmembrane anterior posterior transformation 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6NXT6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (17)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (58)
1 – 10 of 58
RIC3
Tbio
Novelty:  0.0162412
p_int:  0.999997822
p_ni:  0.000002165
p_wrong:  1.3e-8
Score:  0.187
Data Source:  BioPlex,STRINGDB
TXNDC15
Tdark
Novelty:  0.23488442
p_int:  0.999995996
p_ni:  0.000003889
p_wrong:  1.15e-7
Score:  0.207
Data Source:  BioPlex,STRINGDB
PBXIP1
Tbio
Novelty:  0.15404864
p_int:  0.999968068
p_ni:  0.000030326
p_wrong:  0.000001606
Data Source:  BioPlex
KCNS3
Tclin
Family:  IC
Novelty:  0.05882087
p_int:  0.999854197
p_ni:  0.000127357
p_wrong:  0.000018446
Score:  0.167
Data Source:  BioPlex,STRINGDB
SEMA7A
Tbio
Novelty:  0.00741605
p_int:  0.999054682
p_ni:  0.000470088
p_wrong:  0.00047523
Score:  0.256
Data Source:  BioPlex,STRINGDB
SLC25A35
Tdark
Family:  Transporter
Novelty:  1.19834062
Score:  0.792
Data Source:  STRINGDB
SUCO
Tdark
Novelty:  0.00074481
Score:  0.763
Data Source:  STRINGDB
HOXC8
Tbio
Family:  TF
Novelty:  0.01042291
Score:  0.754
Data Source:  STRINGDB
MRPL1
Tdark
Novelty:  0.26665795
Score:  0.72
Data Source:  STRINGDB
NSUN7
Tdark
Family:  Enzyme
Novelty:  0.16082462
Score:  0.716
Data Source:  STRINGDB
Publication Statistics
PubMed Score  8.03

PubMed score by year
PubTator Score  1.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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