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Tbio
SLC30A6
Zinc transporter 6

Protein Summary
Description
Zinc-efflux transporter which allocates the cytoplasmic zinc to the trans-Golgi network (TGN) as well as the vesicular compartment. This gene encodes a member of a family of proteins that function as zinc transporters. This protein can regulate subcellular levels of zinc in the Golgi and vesicles. Expression of this gene is altered in the Alzheimer's disease brain plaques. [provided by RefSeq, Aug 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282587
  • ENSP00000282587
  • ENSG00000152683
  • ENST00000357055
  • ENSP00000349563
  • ENST00000379343
  • ENSP00000368648
  • ENST00000435660
  • ENSP00000399005

Symbol
  • ZNT6
  • ZNT6
  • MST103
  • MSTP103
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.93
kinase perturbation
0.81
transcription factor binding site profile
0.74
microRNA
0.64
disease perturbation
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.73   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 144   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.73   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (74)
1 – 10 of 74
SPPL2B
Tchem
Family:  Enzyme
Novelty:  0.0274774
p_int:  0.999940761
p_ni:  0.000059202
p_wrong:  3.6e-8
Data Source:  BioPlex
CSGALNACT2
Tbio
Family:  Enzyme
Novelty:  0.0770692
p_int:  0.999288887
p_ni:  0.000711082
p_wrong:  3.1e-8
Data Source:  BioPlex
MYO18A
Tbio
Novelty:  0.05058328
p_int:  0.998264614
p_ni:  0.001735386
Data Source:  BioPlex
TMED7
Tdark
Novelty:  0.31193294
p_int:  0.997911078
p_ni:  0.002088542
p_wrong:  3.8e-7
Data Source:  BioPlex
CHRNA9
Tchem
Family:  IC
Novelty:  0.05009815
p_int:  0.997826812
p_ni:  0.002173186
p_wrong:  2e-9
Score:  0.391
Data Source:  BioPlex,STRINGDB
METTL9
Tdark
Family:  Enzyme
Novelty:  0.20589257
p_int:  0.996103748
p_ni:  0.003893376
p_wrong:  0.000002876
Data Source:  BioPlex
B3GNT3
Tbio
Family:  Enzyme
Novelty:  0.04325325
p_int:  0.992797187
p_ni:  0.005555278
p_wrong:  0.001647535
Score:  0.522
Data Source:  BioPlex,STRINGDB
RIC3
Tbio
Novelty:  0.0162412
p_int:  0.992471728
p_ni:  0.007528263
p_wrong:  9e-9
Score:  0.486
Data Source:  BioPlex,STRINGDB
TMEM63C
Tdark
Family:  IC
Novelty:  0.02849254
p_int:  0.992116105
p_ni:  0.007661334
p_wrong:  0.000222561
Data Source:  BioPlex
KCNA5
Tclin
Family:  IC
Novelty:  0.00182891
p_int:  0.987134815
p_ni:  0.011587853
p_wrong:  0.001277332
Data Source:  BioPlex
Pathways (10)
Insulin processing (R-HSA-264876)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Insulin processing
Reactome
Metabolism of proteins
Reactome
Metal ion SLC transporters
Reactome
Peptide hormone metabolism
Reactome
SLC-mediated transmembrane transport
Name
Explore in Pharos
Explore in Source
Insulin processing
Metabolism of proteins
Metal ion SLC transporters
Peptide hormone metabolism
SLC-mediated transmembrane transport
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
interleukin 18 measurement
2
2
2
95.1
testosterone measurement
1
2
2
82.2
sex hormone-binding globulin measurement
4
2
4
74
apolipoprotein A 1 measurement
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
interleukin 18 measurement
2
95.1
testosterone measurement
2
82.2
sex hormone-binding globulin measurement
4
74
apolipoprotein A 1 measurement
1
44.2
Find similar targets by:
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 30 member 6
VGNC:7703
746054
Macaque
solute carrier family 30 member 6
709161
Mouse
MGI:2386741
210148
Rat
RGD:1309250
298786
Dog
solute carrier family 30 member 6
VGNC:46351
475716
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 30 member 6
Macaque
solute carrier family 30 member 6
Mouse
Rat
Dog
solute carrier family 30 member 6
Publication Statistics
PubMed Score 13.73
PubMed score by year
PubTator Score 10.57
PubTator score by year