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Tdark
TTI2
TELO2-interacting protein 2

Protein Summary
Description
Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. This gene encodes a regulator of the DNA damage response. The protein is a component of the Triple T complex (TTT) which also includes telomere length regulation protein and TELO2 interacting protein 1. The TTT complex is involved in cellular resistance to DNA damage stresses and may act as a regulator of phosphoinositide-3-kinase-related protein kinase (PIKK) abundance. [provided by RefSeq, May 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360742
  • ENSP00000353971
  • ENSG00000129696
  • ENST00000431156
  • ENSP00000411169
  • ENST00000613904
  • ENSP00000478396

Symbol
  • C8orf41
  • MRT39
  • C8orf41
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
hub protein
0.71
kinase perturbation
0.71
transcription factor binding site profile
0.62
tissue
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.07   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 41   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.07   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 41   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
35
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TELO2 interacting protein 2
VGNC:771
747397
Mouse
MGI:2384576
234138
Rat
RGD:1310414
290811
Dog
TELO2 interacting protein 2
VGNC:47970
608405
Horse
TELO2 interacting protein 2
VGNC:24641
100061066
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TELO2 interacting protein 2
Mouse
Rat
Dog
TELO2 interacting protein 2
Horse
TELO2 interacting protein 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6NXR4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (4)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (38)
1 – 10 of 38
SLC39A9
Tbio
Family:  Transporter
Novelty:  0.06143625
p_int:  0.999813748
p_ni:  0.000186252
Data Source:  BioPlex
APLNR
Tchem
Family:  GPCR
Novelty:  0.00224203
p_int:  0.999698678
p_ni:  0.000286428
p_wrong:  0.000014894
Data Source:  BioPlex
BSG
Tbio
Novelty:  0.0010285
p_int:  0.999450854
p_ni:  0.000549146
Data Source:  BioPlex
OSBPL3
Tbio
Novelty:  0.06106368
p_int:  0.998648501
p_ni:  0.001351499
Score:  0.252
Data Source:  BioPlex,STRINGDB
TNFRSF10C
Tbio
Novelty:  0.0088942
p_int:  0.994498719
p_ni:  0.005355588
p_wrong:  0.000145693
Data Source:  BioPlex
OPRM1
Tclin
Family:  GPCR
Novelty:  0.0003701
p_int:  0.943341416
p_ni:  0.055922777
p_wrong:  0.000735807
Data Source:  BioPlex
TTI1
Tbio
Novelty:  0.05516406
Score:  0.958
Data Source:  STRINGDB
TELO2
Tbio
Novelty:  0.05515633
Score:  0.834
Data Source:  STRINGDB
MAK16
Tdark
Novelty:  0.07717917
Score:  0.732
Data Source:  STRINGDB
UFSP2
Tbio
Family:  Enzyme
Novelty:  0.12630722
Score:  0.721
Data Source:  STRINGDB
Publication Statistics
PubMed Score  8.07

PubMed score by year
PubTator Score  6.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer