Tbio ESRP1 Epithelial splicing regulatory protein 1

Protein Summary

Description

mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (PubMed:19285943). Regulates splicing and expression of genes involved in inner ear development, auditory hair cell differentiation, and cell fate specification in the cochlear epithelium (By similarity). ESPR1 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009 [PubMed 19285943]).[supplied by OMIM, Aug 2009]

Uniprot Accession IDs

• Q6NXG1
• A6NHA8
• A8MPX1
• E9PB47
• Q2M2B0
• Q499G3
• Q6PJ86
• Q9NXL8

Gene Name

• ESRP1

Ensembl ID

• ENST00000358397
• ENSP00000351168
• ENSG00000104413
• ENST00000423620
• ENSP00000407349
• ENST00000433389
• ENSP00000405738
• ENST00000642581
• ENSP00000495733
• ENST00000646773
• ENSP00000494213

Symbol

• RBM35A
• RBM35A
• RMB35A
• DFNB109

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.96
virus perturbation	0.88
PubMedID	0.81
histone modification site profile	0.76
transcription factor binding site profile	0.7

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / Epithelial Splicing Regulatory Protein 1

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / Epithelial Splicing Regulatory Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.65   (req: < 5)

Gene RIFs: 48   (req: <= 3)

Antibodies: 142   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.65   (req: >= 5)

Gene RIFs: 48   (req: > 3)

Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0