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Tbio
ESRP1
Epithelial splicing regulatory protein 1

Protein Summary
Description
mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (PubMed:19285943). Regulates splicing and expression of genes involved in inner ear development, auditory hair cell differentiation, and cell fate specification in the cochlear epithelium (By similarity). ESPR1 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009 [PubMed 19285943]).[supplied by OMIM, Aug 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358397
  • ENSP00000351168
  • ENSG00000104413
  • ENST00000423620
  • ENSP00000407349
  • ENST00000433389
  • ENSP00000405738
  • ENST00000642581
  • ENSP00000495733
  • ENST00000646773
  • ENSP00000494213

Symbol
  • RBM35A
  • RBM35A
  • RMB35A
  • DFNB109
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.96
virus perturbation
0.88
PubMedID
0.81
histone modification site profile
0.76
transcription factor binding site profile
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.11   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.11   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
2
3
67.1
urate measurement
1
1
1
21.5
blood protein measurement
1
1
1
9.8
body height
1
1
1
9.5
self reported educational attainment
1
1
1
2.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
67.1
urate measurement
1
21.5
blood protein measurement
1
9.8
body height
1
9.5
self reported educational attainment
1
2.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
epithelial splicing regulatory protein 1
VGNC:880
464289
Macaque
epithelial splicing regulatory protein 1
700009
Mouse
MGI:1917326
207920
Rat
RGD:1560481
500409
Dog
epithelial splicing regulatory protein 1
VGNC:40478
487054
Species
Name
OMA
EggNOG
Inparanoid
Chimp
epithelial splicing regulatory protein 1
Macaque
epithelial splicing regulatory protein 1
Mouse
Rat
Dog
epithelial splicing regulatory protein 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q6NXG1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
FGFR2 alternative splicing
Reactome
Oncogenic MAPK signaling
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Disease
Diseases of signal transduction
FGFR2 alternative splicing
Oncogenic MAPK signaling
Signal Transduction
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (157)
1 – 10 of 157
RGPD8
Tdark
Novelty:  0.12397737
p_int:  0.99999969
p_ni:  3.1e-7
Score:  0.183
Data Source:  BioPlex,STRINGDB
RGPD5
Tbio
Novelty:  0.13776125
p_int:  0.999989367
p_ni:  0.000010633
Data Source:  BioPlex
RBPMS
Tbio
Novelty:  0.01727259
p_int:  0.999873654
p_ni:  0.000126346
Score:  0.809
Data Source:  BioPlex,STRINGDB
RGPD3
Tdark
Novelty:  0.66363867
p_int:  0.999712796
p_ni:  0.000287204
Score:  0.219
Data Source:  BioPlex,STRINGDB
RBPMS2
Tbio
Novelty:  0.14005113
p_int:  0.999339105
p_ni:  0.000093462
p_wrong:  0.000567432
Score:  0.909
Data Source:  BioPlex,STRINGDB
ATXN2
Tbio
Novelty:  0.00373116
p_int:  0.973490606
p_ni:  0.026509394
Score:  0.514
Data Source:  BioPlex,STRINGDB
THUMPD3
Tdark
Novelty:  0.23224828
p_int:  0.966294575
p_ni:  0.033705423
p_wrong:  2e-9
Data Source:  BioPlex
ZNF703
Tbio
Novelty:  0.03956045
p_int:  0.938617008
p_ni:  0.061382697
p_wrong:  2.94e-7
Score:  0.249
Data Source:  BioPlex,STRINGDB
HELZ
Tbio
Family:  Enzyme
Novelty:  0.08786982
p_int:  0.92134876
p_ni:  0.07865124
Score:  0.228
Data Source:  BioPlex,STRINGDB
ELAVL2
Tbio
Novelty:  0.00370708
p_int:  0.897566563
p_ni:  0.091591464
p_wrong:  0.010841973
Score:  0.499
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  69.11

PubMed score by year
PubTator Score  34.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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