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Tbio
RGMB
RGM domain family member B

Protein Summary
Description
Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth. RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule family (see RGMA, MIM 607362) and contributes to the patterning of the developing nervous system (Samad et al., 2005 [PubMed 15671031]).[supplied by OMIM, Apr 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000513185
  • ENSP00000423256
  • ENSG00000174136

Symbol
  • DRAGON
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
tissue sample
0.8
PubMedID
0.77
transcription factor binding site profile
0.76
microRNA
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.14   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 203   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.14   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Netrin-1 signaling
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Netrin-1 signaling
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
HGNC
Protein-Protein Interactions (58)
1 – 10 of 58
BMP2
Tbio
Novelty: 0.00020018
Score: 0.998
Data Source: STRINGDB
BMP4
Tchem
Novelty: 0.00057391
Score: 0.99
Data Source: STRINGDB
NEO1
Tbio
Novelty: 0.00791811
Score: 0.984
Data Source: Reactome,STRINGDB
BMPR1B
Tchem
Family: Kinase
Novelty: 0.00996192
Score: 0.962
Data Source: STRINGDB
BMPR1A
Tchem
Family: Kinase
Novelty: 0.00472897
Score: 0.947
Data Source: STRINGDB
NOG
Tbio
Novelty: 0.00131071
Score: 0.945
Data Source: STRINGDB
BAMBI
Tbio
Novelty: 0.00637661
Score: 0.94
Data Source: STRINGDB
BMPR2
Tchem
Family: Kinase
Novelty: 0.00191079
Score: 0.935
Data Source: STRINGDB
CHRD
Tbio
Novelty: 0.00426792
Score: 0.928
Data Source: STRINGDB
SMAD5
Tbio
Family: TF
Novelty: 0.00607935
Score: 0.927
Data Source: STRINGDB
Publication Statistics
PubMed Score  131.14

PubMed score by year
PubTator Score  30.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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