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Tbio
MFSD12
Major facilitator superfamily domain-containing protein 12

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355415
  • ENSP00000347583
  • ENSG00000161091
  • ENST00000389395
  • ENSP00000374046
  • ENST00000588918
  • ENSP00000467207

Symbol
  • C19orf28
  • PP3501
  • C19orf28
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.83
gene perturbation
0.7
transcription factor perturbation
0.68
transcription factor
0.67
cellular component
0.65


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.94   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 66   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.94   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.5
29.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.5
29.8
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
major facilitator superfamily domain containing 12
713171
Mouse
MGI:3604804
73822
Rat
RGD:1307722
362824
Dog
major facilitator superfamily domain containing 12
VGNC:43198
485058
Cow
major facilitator superfamily domain containing 12 [Source:HGNC Symbol;Acc:HGNC:28299]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
major facilitator superfamily domain containing 12
Mouse
Rat
Dog
major facilitator superfamily domain containing 12
Cow
major facilitator superfamily domain containing 12 [Source:HGNC Symbol;Acc:HGNC:28299]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6NUT3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (37)
1 – 10 of 37
SLC22A9
Tbio
Family: Transporter
Novelty: 0.02212992
p_int: 0.999001546
p_ni: 0.000866294
p_wrong: 0.000132159
Data Source: BioPlex
LPAR1
Tchem
Family: GPCR
Novelty: 0.00318056
p_int: 0.9949557
p_ni: 0.005039085
p_wrong: 0.000005215
Data Source: BioPlex
PMEL
Tbio
Novelty: 0.00116525
p_int: 0.988140919
p_ni: 0.001686875
p_wrong: 0.010172206
Score: 0.204
Data Source: BioPlex,STRINGDB
SYPL2
Tdark
Novelty: 0.03928948
p_int: 0.987631013
p_ni: 0.003175793
p_wrong: 0.009193194
Score: 0.289
Data Source: BioPlex,STRINGDB
SLC39A4
Tbio
Family: Transporter
Novelty: 0.00742159
p_int: 0.976865587
p_ni: 0.023090071
p_wrong: 0.000044343
Score: 0.178
Data Source: BioPlex,STRINGDB
TSPAN31
Tbio
Novelty: 0.13580467
p_int: 0.835191705
p_ni: 0.001547022
p_wrong: 0.163261273
Data Source: BioPlex
FZR1
Tbio
Novelty: 0.01599606
Score: 0.907
Data Source: STRINGDB
MFSD9
Tdark
Novelty: 0.98582986
Score: 0.773
Data Source: STRINGDB
MFSD13A
Tdark
Novelty: 0.39321369
Score: 0.771
Data Source: STRINGDB
MFSD6L
Tdark
Novelty: 1.62242256
Score: 0.769
Data Source: STRINGDB
Publication Statistics
PubMed Score  7.94

PubMed score by year
PubTator Score  1.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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