Protein Summary
Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). May be involved in apoptosis regulation. Necessary for signal transduction through the sonic hedgehog (Shh) signaling pathway. This gene encodes a member of the tectonic gene family which functions in Hedgehog signal transduction and development of the neural tube. Mutations in this gene have been associated with Orofaciodigital Syndrome IV and Joubert Syndrom 18. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2012]
- ENST00000371209
- ENSP00000360253
- ENSG00000119977
- ENST00000371217
- ENSP00000360261
- ENST00000430368
- ENSP00000387567
- ENST00000614499
- ENSP00000483364
- C10orf61
- TECT3
- OFD4
- TECT3
- JBTS18
- C10orf61
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.9 | ||
kinase perturbation | 0.88 | ||
tissue sample | 0.71 | ||
disease perturbation | 0.62 | ||
cellular component | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.08 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 181 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.08 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 181 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0