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Tbio
ACSM5
Acyl-coenzyme A synthetase ACSM5, mitochondrial

Protein Summary
Description
Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro) (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331849
  • ENSP00000327916
  • ENSG00000183549
  • ENST00000575584
  • ENSP00000460112

Symbol
  • MACS3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
molecular function
0.94
tissue sample
0.61
pathway
0.59
cell line
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.28   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.28   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
1
1
43.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
43.3
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA synthetase medium chain family member 5
VGNC:13652
107968805
Macaque
acyl-CoA synthetase medium chain family member 5
696124
Mouse
MGI:2444086
272428
Rat
RGD:1309578
361637
Dog
acyl-CoA synthetase medium chain family member 5
VGNC:37536
609009
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA synthetase medium chain family member 5
Macaque
acyl-CoA synthetase medium chain family member 5
Mouse
Rat
Dog
acyl-CoA synthetase medium chain family member 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6NUN0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Amino Acid conjugation (R-HSA-156587)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amino Acid conjugation
Reactome
Biological oxidations
Reactome
Conjugation of carboxylic acids
Reactome
Conjugation of salicylate with glycine
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Amino Acid conjugation
Biological oxidations
Conjugation of carboxylic acids
Conjugation of salicylate with glycine
Metabolism
Gene Ontology Terms (10)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (36)
1 – 10 of 36
ACSF2
Tbio
Family: Enzyme
Novelty: 0.10280059
p_int: 0.999520755
p_ni: 0.000479245
Score: 0.32
Data Source: BioPlex,STRINGDB
PDPR
Tbio
Family: Enzyme
Novelty: 0.04223174
p_int: 0.995395974
p_ni: 0.004604026
Score: 0.234
Data Source: BioPlex,STRINGDB
POLG
Tchem
Family: Enzyme
Novelty: 0.00172189
p_int: 0.988944885
p_ni: 0.011055115
Score: 0.191
Data Source: BioPlex,STRINGDB
NARS2
Tbio
Family: Enzyme
Novelty: 0.01879317
p_int: 0.987440794
p_ni: 0.012555817
p_wrong: 0.000003389
Score: 0.172
Data Source: BioPlex,STRINGDB
FDXR
Tbio
Family: Enzyme
Novelty: 0.00171588
p_int: 0.986900098
p_ni: 0.013099902
Score: 0.193
Data Source: BioPlex,STRINGDB
PCCA
Tbio
Family: Enzyme
Novelty: 0.00515417
p_int: 0.95938715
p_ni: 0.040612242
p_wrong: 6.08e-7
Score: 0.248
Data Source: BioPlex,STRINGDB
LARS2
Tbio
Family: Enzyme
Novelty: 0.00543895
p_int: 0.940606736
p_ni: 0.059393264
Score: 0.186
Data Source: BioPlex,STRINGDB
CPS1
Tclin
Family: Enzyme
Novelty: 0.00917469
p_int: 0.925337111
p_ni: 0.074662889
Score: 0.244
Data Source: BioPlex,STRINGDB
NUDT19
Tdark
Novelty: 0.26928757
p_int: 0.912703227
p_ni: 0.059527071
p_wrong: 0.027769702
Score: 0.213
Data Source: BioPlex,STRINGDB
MCCC1
Tbio
Family: Enzyme
Novelty: 0.01234441
p_int: 0.868817517
p_ni: 0.131182483
Score: 0.267
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  7.28

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer