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Tdark
RETSAT
All-trans-retinol 13,14-reductase

Protein Summary
Description
Catalyzes the saturation of all-trans-retinol to all-trans-13,14-dihydroretinol. Does not exhibit any activity toward all-trans-retinoic acid, nor 9-cis, 11-cis or 13-cis-retinol isomers. May play a role in the metabolism of vitamin A. Independently of retinol conversion, may regulate liver metabolism upstream of MLXIPL/ChREBP. May play a role in adipocyte differentiation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295802
  • ENSP00000295802
  • ENSG00000042445

Symbol
  • PPSIG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
transcription factor perturbation
0.94
kinase perturbation
0.93
histone modification site profile
0.91
transcription factor binding site profile
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.35   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 16   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.35   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 16   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (65)
CDHR5
Tbio
Novelty:  0.08525208
p_int:  0.996295102
p_ni:  0.003704898
Score:  0.203
Data Source:  BioPlex,STRINGDB
SCN3B
Tbio
Family:  IC
Novelty:  0.0438123
p_int:  0.991951344
p_ni:  0.008048656
Data Source:  BioPlex
IL9R
Tbio
Novelty:  0.04444351
p_int:  0.986537555
p_ni:  0.013462445
Score:  0.179
Data Source:  BioPlex,STRINGDB
IL17RB
Tbio
Novelty:  0.01540031
p_int:  0.974393835
p_ni:  0.025606165
Data Source:  BioPlex
PCDHGB4
Tdark
Novelty:  0.25018904
p_int:  0.974102502
p_ni:  0.025897498
Data Source:  BioPlex
SPINT2
Tbio
Family:  Enzyme
Novelty:  0.0046602
p_int:  0.966940815
p_ni:  0.033059185
Data Source:  BioPlex
RXFP1
Tchem
Family:  GPCR
Novelty:  0.00580827
p_int:  0.963927152
p_ni:  0.036072848
Data Source:  BioPlex
PMEL
Tbio
Novelty:  0.00116525
p_int:  0.96306122
p_ni:  0.03693878
Data Source:  BioPlex
GDPD5
Tbio
Family:  Enzyme
Novelty:  0.05871733
p_int:  0.960058991
p_ni:  0.039941009
Score:  0.165
Data Source:  BioPlex,STRINGDB
TMPRSS3
Tbio
Family:  Enzyme
Novelty:  0.0268524
p_int:  0.941520899
p_ni:  0.058479101
Data Source:  BioPlex
Pathways (11)
G alpha (i) signalling events (R-HSA-418594)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Metabolism
Reactome
Metabolism of fat-soluble vitamins
Reactome
Metabolism of vitamins and cofactors
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
GPCR downstream signalling
Metabolism
Metabolism of fat-soluble vitamins
Metabolism of vitamins and cofactors
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
2
3
88.8
platelet count
1
1
1
68.8
heel bone mineral density
2
2
2
68.5
high density lipoprotein cholesterol measurement
2
2
3
59.7
bone density
1
2
2
39.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
88.8
platelet count
1
68.8
heel bone mineral density
2
68.5
high density lipoprotein cholesterol measurement
3
59.7
bone density
2
39.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
retinol saturase
VGNC:10749
470420
Macaque
retinol saturase
695058
Mouse
MGI:1914692
67442
Rat
RGD:628802
246298
Dog
retinol saturase
VGNC:45486
483083
Species
Name
OMA
EggNOG
Inparanoid
Chimp
retinol saturase
Macaque
retinol saturase
Mouse
Rat
Dog
retinol saturase
Publication Statistics
PubMed Score 12.35
PubMed score by year
PubTator Score 3.74
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title