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Tbio
REEP3
Receptor expression-enhancing protein 3

Protein Classes
Protein Summary
Description
Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373758
  • ENSP00000362863
  • ENSG00000165476

Symbol
  • C10orf74
  • Yip2b
  • C10orf74
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
microRNA
0.88
transcription factor binding site profile
0.85
transcription factor perturbation
0.84
histone modification site profile
0.82


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.86   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 70   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.86   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
2
4
95.6
triglyceride measurement
3
2
3
90.8
waist-hip ratio
2
1
2
90.6
2
2
0
1.1
80.2
glycine measurement
1
1
1
64
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
95.6
triglyceride measurement
3
90.8
waist-hip ratio
2
90.6
0
1.1
80.2
glycine measurement
1
64
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
receptor accessory protein 3
VGNC:12454
748583
Macaque
receptor accessory protein 3
697494
Mouse
MGI:88930
28193
Rat
RGD:1560401
294375
Dog
receptor accessory protein 3
VGNC:45462
479222
Species
Name
OMA
EggNOG
Inparanoid
Chimp
receptor accessory protein 3
Macaque
receptor accessory protein 3
Mouse
Rat
Dog
receptor accessory protein 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6NUK4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
G alpha (s) signalling events (R-HSA-418555)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
Olfactory Signaling Pathway
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (s) signalling events
GPCR downstream signalling
Olfactory Signaling Pathway
Signal Transduction
Signaling by GPCR
Gene Ontology Terms (6)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (409)
1 – 10 of 409
OR2AE1
Tdark
Family: oGPCR
Novelty: 1.90973522
Score: 0.942
Data Source: STRINGDB
OR9G1
Tdark
Family: oGPCR
Novelty: 1.79956118
Score: 0.932
Data Source: STRINGDB
OR51E2
Tbio
Family: oGPCR
Novelty: 0.02435259
Score: 0.905
Data Source: STRINGDB
OR5J2
Tdark
Family: oGPCR
Novelty: 3.65419635
Score: 0.904
Data Source: STRINGDB
OR13G1
Tdark
Family: oGPCR
Novelty: 0.63690138
Score: 0.904
Data Source: STRINGDB
OR1L8
Tdark
Family: oGPCR
Novelty: 12.32613054
Score: 0.904
Data Source: STRINGDB
OR2AJ1
Tdark
Family: oGPCR
Score: 0.903
Data Source: STRINGDB
OR2T1
Tdark
Family: oGPCR
Novelty: 9.57942984
Score: 0.902
Data Source: STRINGDB
OR5AC2
Tdark
Family: oGPCR
Novelty: 0.20913736
Score: 0.902
Data Source: STRINGDB
OR2T33
Tdark
Family: oGPCR
Novelty: 3.72313669
Score: 0.902
Data Source: STRINGDB
Publication Statistics
PubMed Score  4.86

PubMed score by year
PubTator Score  1.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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