Tbio SLC25A24 Calcium-binding mitochondrial carrier protein SCaMC-1

Protein Summary

Description

Calcium-dependent mitochondrial solute carrier. Mediates the reversible, electroneutral exchange of Mg-ATP or Mg-ADP against phosphate ions, catalyzing the net uptake or efflux of adenine nucleotides across the mitochondrial inner membrane. Nucleotide transport is inactive when cytosolic calcium levels are low, and is activated by an increase in cytosolic calcium levels. May play a role in protecting cells against oxidative stress-induced cell death, probably by promoting the formation of calcium-phosphate precipitates in the mitochondrial matrix, and thereby buffering calcium levels in the mitochondrial matrix. This gene encodes a carrier protein that transports ATP-Mg exchanging it for phosphate. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Uniprot Accession IDs

• Q6NUK1
• B7ZAI9
• Q5T331
• Q5T485
• Q6PJJ9
• Q705K4
• Q9P129

Gene Name

• SLC25A24

Ensembl ID

• ENST00000370041
• ENSP00000359058
• ENSG00000085491
• ENST00000565488
• ENSP00000457733
• ENST00000639032
• ENSP00000492810
• ENSG00000284468
• ENST00000640416
• ENSP00000491572

Symbol

• APC1
• MCSC1
• SCAMC1
• APC1
• SCAMC1
• SCAMC-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
protein domain	0.92
molecular function	0.81
interacting protein	0.75
PubMedID	0.73

Protein Classes

PANTHER Classes

Protein / Transporter / Mitochondrial Carrier Protein / Calcium-binding Mitochondrial Carrier Protein Scamc-1

Protein / Transporter / Amino Acid Transporter / Calcium-binding Mitochondrial Carrier Protein Scamc-1

Protein / Transfer/carrier Protein / Calcium-binding Mitochondrial Carrier Protein Scamc-1

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Calcium-binding Mitochondrial Carrier Protein Scamc-1

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc25 Family Of Mitochondrial Transporters / Mitochondrial Nucleotide Transporter Subfamily / Calcium-binding Mitochondrial Carrier Protein Scamc-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.75   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 123   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.75   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 123   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0