You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SLC25A24
Calcium-binding mitochondrial carrier protein SCaMC-1

Protein Classes
Protein Summary
Description
Calcium-dependent mitochondrial solute carrier. Mediates the reversible, electroneutral exchange of Mg-ATP or Mg-ADP against phosphate ions, catalyzing the net uptake or efflux of adenine nucleotides across the mitochondrial inner membrane. Nucleotide transport is inactive when cytosolic calcium levels are low, and is activated by an increase in cytosolic calcium levels. May play a role in protecting cells against oxidative stress-induced cell death, probably by promoting the formation of calcium-phosphate precipitates in the mitochondrial matrix, and thereby buffering calcium levels in the mitochondrial matrix. This gene encodes a carrier protein that transports ATP-Mg exchanging it for phosphate. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370041
  • ENSP00000359058
  • ENSG00000085491
  • ENST00000565488
  • ENSP00000457733
  • ENST00000639032
  • ENSP00000492810
  • ENSG00000284468
  • ENST00000640416
  • ENSP00000491572

Symbol
  • APC1
  • MCSC1
  • SCAMC1
  • APC1
  • SCAMC1
  • SCAMC-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
protein domain
0.92
molecular function
0.81
interacting protein
0.75
PubMedID
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.02   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 123   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.02   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 123   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (18)
Items per page:
1 – 5 of 18
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
2
3
84.8
neutrophil count
3
2
3
84.8
myeloid white cell count
2
2
2
80.8
myeloid white cell count
2
2
2
80.8
leukocyte count
2
2
2
49.5
Items per page:
1 – 5 of 18
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
84.8
neutrophil count
3
84.8
myeloid white cell count
2
80.8
myeloid white cell count
2
80.8
leukocyte count
2
49.5
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (45)
1 – 10 of 45
CMTM8
Tbio
Novelty: 0.0953768
p_int: 0.999617251
p_ni: 0.00038273
p_wrong: 1.9e-8
Data Source: BioPlex
APLNR
Tchem
Family: GPCR
Novelty: 0.00224203
p_int: 0.999409021
p_ni: 0.000590972
p_wrong: 6e-9
Data Source: BioPlex
TMEM108
Tbio
Novelty: 0.08687599
p_int: 0.998973255
p_ni: 0.001026744
Data Source: BioPlex
TMEM171
Tdark
Novelty: 2.00247773
p_int: 0.998745381
p_ni: 0.001254619
Data Source: BioPlex
SLC39A9
Tbio
Family: Transporter
Novelty: 0.06143625
p_int: 0.998477764
p_ni: 0.001522236
Score: 0.175
Data Source: BioPlex,STRINGDB
SLC1A5
Tchem
Family: Transporter
Novelty: 0.00201741
p_int: 0.99829112
p_ni: 0.001708846
p_wrong: 3.4e-8
Score: 0.186
Data Source: BioPlex,STRINGDB
CMKLR1
Tchem
Family: GPCR
Novelty: 0.00893083
p_int: 0.994442235
p_ni: 0.005553542
p_wrong: 0.000004223
Data Source: BioPlex
SLC15A1
Tchem
Family: Transporter
Novelty: 0.00149723
p_int: 0.990834425
p_ni: 0.009165383
p_wrong: 1.92e-7
Data Source: BioPlex
MFSD4A
Tdark
Novelty: 0.62186415
p_int: 0.986325942
p_ni: 0.013673765
p_wrong: 2.93e-7
Score: 0.183
Data Source: BioPlex,STRINGDB
MGARP
Tbio
Novelty: 0.02883753
p_int: 0.98512956
p_ni: 0.014835914
p_wrong: 0.000034526
Data Source: BioPlex
Publication Statistics
PubMed Score  17.02

PubMed score by year
PubTator Score  54.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: