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Tdark
PWWP2B
PWWP domain-containing protein 2B

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305233
  • ENSP00000306324
  • ENSG00000171813
  • ENST00000631148
  • ENSP00000486501

Symbol
  • PWWP2
  • PWWP2
  • pp8607
  • bA432J24.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.84
gene perturbation
0.83
histone modification site profile
0.76
transcription factor binding site profile
0.67
transcription factor
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.68   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 71   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.68   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at first sexual intercourse measurement
2
2
2
76.7
risky sexual behaviour measurement
1
1
1
44.2
heel bone mineral density
1
1
1
9.1
coffee consumption measurement
1
1
1
5.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at first sexual intercourse measurement
2
76.7
risky sexual behaviour measurement
1
44.2
heel bone mineral density
1
9.1
coffee consumption measurement
1
5.6
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PWWP domain containing 2B
VGNC:5711
450837
Macaque
PWWP domain containing 2B [Source:HGNC Symbol;Acc:HGNC:25150]
Mouse
MGI:2142008
101631
Rat
RGD:1307108
361671
Horse
PWWP domain containing 2B
VGNC:22053
100051318
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PWWP domain containing 2B
Macaque
PWWP domain containing 2B [Source:HGNC Symbol;Acc:HGNC:25150]
Mouse
Rat
Horse
PWWP domain containing 2B
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q6NUJ5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (1)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Protein-Protein Interactions (15)
1 – 10 of 15
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
p_int:  0.998444191
p_ni:  0.000001176
p_wrong:  0.001554633
Score:  0.186
Data Source:  BioPlex,STRINGDB
P4HA3
Tbio
Family:  Enzyme
Novelty:  0.03832564
p_int:  0.975590141
p_ni:  4.4e-8
p_wrong:  0.024409815
Data Source:  BioPlex
HDGFL1
Tdark
Family:  Epigenetic
Novelty:  0.14333428
Score:  0.67
Data Source:  STRINGDB
BRD2
Tchem
Family:  Epigenetic
Novelty:  0.00531003
Score:  0.586
Data Source:  STRINGDB
VPS4B
Tchem
Novelty:  0.00788708
Score:  0.58
Data Source:  STRINGDB
EGLN3
Tclin
Novelty:  0.00643992
Score:  0.547
Data Source:  STRINGDB
VPS4A
Tbio
Novelty:  0.01508121
Score:  0.532
Data Source:  STRINGDB
EGLN2
Tclin
Novelty:  0.00570785
Score:  0.517
Data Source:  STRINGDB
NSD3
Tbio
Family:  Epigenetic
Novelty:  0.02371017
Score:  0.497
Data Source:  STRINGDB
NSD1
Tbio
Family:  Epigenetic
Novelty:  0.00495576
Score:  0.464
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1.68

PubMed score by year
PubTator Score  0.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer