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Tdark
PSAPL1
Proactivator polypeptide-like 1

Protein Summary
Description
May activate the lysosomal degradation of sphingolipids. This gene encodes a protein that is related to the glycoprotein prosaposin. Based on sequence similarity between the encoded protein and prosaposin, it is predicted that the encoded protein is a preproprotein that is proteolytically processed to generate multiple protein products. These predicted products include saposins A-like, B-like, C-like, and D-like, which may play a role in the lysosomal degradation of sphingolipids. [provided by RefSeq, Jul 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319098
  • ENSP00000317445
  • ENSG00000178597
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
cell type or tissue
0.72
cell line
0.55
virus perturbation
0.5
transcription factor
0.47


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.98   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.98   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (22)
1 – 10 of 22
PSAP
Tbio
Novelty:  0.00395347
Score:  0.803
Data Source:  STRINGDB
ZNF655
Tbio
Family:  TF
Novelty:  0.02852796
Score:  0.702
Data Source:  STRINGDB
PCIF1
Tbio
Novelty:  0.08599436
Score:  0.663
Data Source:  STRINGDB
TSC22D2
Tdark
Family:  TF
Novelty:  0.30718123
Score:  0.649
Data Source:  STRINGDB
TMEM159
Tdark
Novelty:  0.22237677
Score:  0.617
Data Source:  STRINGDB
SH3TC1
Tdark
Novelty:  1.6405708
Score:  0.577
Data Source:  STRINGDB
BPNT1
Tbio
Family:  Enzyme
Novelty:  0.1114547
Score:  0.522
Data Source:  STRINGDB
ABLIM2
Tdark
Novelty:  0.23629309
Score:  0.505
Data Source:  STRINGDB
ABHD14B
Tdark
Family:  Enzyme
Novelty:  0.32505221
Score:  0.501
Data Source:  STRINGDB
C1QBP
Tbio
Novelty:  0.00532825
Score:  0.477
Data Source:  STRINGDB
Gene Ontology Terms (8)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
30.2
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
prosaposin like 1
VGNC:48978
100609404
Mouse
MGI:1924193
76943
Rat
RGD:1307368
289720
Horse
prosaposin like 1
VGNC:51283
102150352
Cow
prosaposin like 1
VGNC:53773
529295
Species
Name
OMA
EggNOG
Inparanoid
Chimp
prosaposin like 1
Mouse
Rat
Horse
prosaposin like 1
Cow
prosaposin like 1
Publication Statistics
PubMed Score 0.98
PubMed score by year