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Tbio
RHBDD2
Rhomboid domain-containing protein 2

Protein Classes
Protein Summary
Description
The protein encoded by this gene is a member of the rhomboid family of membrane-bound proteases and is overexpressed in some breast cancers. Members of this family are involved in intramembrane proteolysis. In mouse, the orthologous protein associates with the Golgi body. [provided by RefSeq, Sep 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000006777
  • ENSP00000006777
  • ENSG00000005486
  • ENST00000318622
  • ENSP00000314144
  • ENST00000428119
  • ENSP00000391232

Symbol
  • RHBDL7
  • NPD007
  • RHBDL7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.82
histone modification site profile
0.78
cell type or tissue
0.72
disease perturbation
0.62
cellular component
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.62   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 43   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.62   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 43   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
CCL24 measurement
1
1
1
88.3
eosinophil percentage of leukocytes
2
3
3
72
eosinophil count
2
3
3
70.8
eosinophil percentage of granulocytes
1
2
2
68.2
sum of eosinophil and basophil counts
1
2
2
67.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
CCL24 measurement
1
88.3
eosinophil percentage of leukocytes
3
72
eosinophil count
3
70.8
eosinophil percentage of granulocytes
2
68.2
sum of eosinophil and basophil counts
2
67.2
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
rhomboid domain containing 2
VGNC:4494
463480
Macaque
rhomboid domain containing 2
720005
Mouse
MGI:1915612
215160
Rat
RGD:1308231
360793
Dog
rhomboid domain containing 2
VGNC:45544
489815
Species
Name
OMA
EggNOG
Inparanoid
Chimp
rhomboid domain containing 2
Macaque
rhomboid domain containing 2
Mouse
Rat
Dog
rhomboid domain containing 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6NTF9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (37)
1 – 10 of 37
MIC13
Tbio
Novelty: 0.03686888
Score: 0.747
Data Source: STRINGDB
RHBDD1
Tbio
Family: Enzyme
Novelty: 0.10354568
Score: 0.732
Data Source: STRINGDB
RHBDF1
Tbio
Family: Enzyme
Novelty: 0.01942693
Score: 0.72
Data Source: STRINGDB
RHBDL2
Tbio
Family: Enzyme
Novelty: 0.07665239
Score: 0.699
Data Source: STRINGDB
PARL
Tbio
Family: Enzyme
Novelty: 0.01317944
Score: 0.688
Data Source: STRINGDB
GRTP1
Tdark
Novelty: 0.8841166
Score: 0.644
Data Source: STRINGDB
RHBDL1
Tdark
Family: Enzyme
Novelty: 0.63616927
Score: 0.635
Data Source: STRINGDB
VNN2
Tbio
Novelty: 0.02286648
Score: 0.611
Data Source: STRINGDB
ZBTB34
Tdark
Family: TF
Novelty: 0.5693361
Score: 0.591
Data Source: STRINGDB
RHBDF2
Tbio
Family: Enzyme
Novelty: 0.02487334
Score: 0.579
Data Source: STRINGDB
Publication Statistics
PubMed Score  7.62

PubMed score by year
PubTator Score  4.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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