APOBEC3H
DNA dC->dU-editing enzyme APOBEC-3H
Protein Summary
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. The A3H-var/haplotype 2 exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against T-cell leukemia virus type 1 (HTLV-1) and may inhibit the ...more
- ENST00000348946
- ENSP00000216123
- ENSG00000100298
- ENST00000401756
- ENSP00000385741
- ENST00000442487
- ENSP00000411754
- ENST00000613677
- ENSP00000483689
- A3H
- ARP10
- ARP-10
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.72 | ||
tissue sample | 0.61 | ||
protein domain | 0.58 | ||
cellular component | 0.52 | ||
biological term | 0.5 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 71.29 (req: < 5)
Gene RIFs: 37 (req: <= 3)
Antibodies: 39 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 71.29 (req: >= 5)
Gene RIFs: 37 (req: > 3)
Antibodies: 39 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (17)
Nearest Tclin Targets
Pathways (5)
Reactome (4)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Formation of the Editosome | ||||
Reactome | Metabolism of RNA | ||||
Reactome | mRNA Editing | ||||
Reactome | mRNA Editing: C to U Conversion | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Formation of the Editosome | ||||
Metabolism of RNA | ||||
mRNA Editing | ||||
mRNA Editing: C to U Conversion | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (3)
Components (3)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
3 | 3 | 0 | 1.2 | 91.4 | |||||
lymphocyte count | 3 | 1 | 3 | 84 | |||||
myeloid white cell count | 1 | 1 | 1 | 77.6 | |||||
monocyte count | 1 | 1 | 1 | 76.1 | |||||
leukocyte count | 2 | 3 | 3 | 75.4 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.2 | 91.4 | |||||
lymphocyte count | 3 | 84 | |||||
myeloid white cell count | 1 | 77.6 | |||||
monocyte count | 1 | 76.1 | |||||
leukocyte count | 3 | 75.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (2)
1 – 2 of 2
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | apolipoprotein B mRNA editing enzyme catalytic subunit 3H | VGNC:6685 | 470214 | |||||
Macaque | apolipoprotein B mRNA editing enzyme catalytic subunit 3H | 723811 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | apolipoprotein B mRNA editing enzyme catalytic subunit 3H | |||||
Macaque | apolipoprotein B mRNA editing enzyme catalytic subunit 3H | |||||
Publication Statistics
PubMed Score 71.29
PubMed score by year
PubTator Score 38.00
PubTator score by year
Related Publications
Text Mined References (56)
GeneRif Annotations (37)
Items per page:
0 of 0
PMID | Year | Title |
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