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Tbio
APOBEC3H
DNA dC->dU-editing enzyme APOBEC-3H

Protein Summary
Description
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. The A3H-var/haplotype 2 exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against T-cell leukemia virus type 1 (HTLV-1) and may inhibit the ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000348946
  • ENSP00000216123
  • ENSG00000100298
  • ENST00000401756
  • ENSP00000385741
  • ENST00000442487
  • ENSP00000411754
  • ENST00000613677
  • ENSP00000483689

Symbol
  • A3H
  • ARP10
  • ARP-10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.72
tissue sample
0.61
protein domain
0.58
cellular component
0.52
biological term
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.29   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 39   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.29   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 39   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (17)
APOBEC4
Tdark
Novelty:  0.13240154
Score:  0.977
Data Source:  STRINGDB
A1CF
Tbio
Novelty:  0.04151936
Score:  0.926
Data Source:  STRINGDB
APOBEC2
Tbio
Novelty:  0.03447716
Score:  0.924
Data Source:  STRINGDB
APOBEC1
Tbio
Novelty:  0.00622042
Score:  0.923
Data Source:  STRINGDB
APOBEC3B
Tbio
Novelty:  0.008531
Score:  0.92
Data Source:  STRINGDB
APOBEC3A
Tchem
Novelty:  0.00982993
Score:  0.92
Data Source:  STRINGDB
APOBEC3C
Tbio
Novelty:  0.00882074
Score:  0.919
Data Source:  STRINGDB
CDA
Tclin
Family:  Enzyme
Novelty:  0.00280981
Score:  0.729
Data Source:  STRINGDB
CUL5
Tbio
Novelty:  0.00792494
Score:  0.669
Data Source:  STRINGDB
APOB
Tchem
Novelty:  0.00008247
Score:  0.646
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Formation of the Editosome (R-HSA-75094)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Formation of the Editosome
Reactome
Metabolism of RNA
Reactome
mRNA Editing
Reactome
mRNA Editing: C to U Conversion
Name
Explore in Pharos
Explore in Source
Formation of the Editosome
Metabolism of RNA
mRNA Editing
mRNA Editing: C to U Conversion
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
1.2
91.4
lymphocyte count
3
1
3
84
myeloid white cell count
1
1
1
77.6
monocyte count
1
1
1
76.1
leukocyte count
2
3
3
75.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
91.4
lymphocyte count
3
84
myeloid white cell count
1
77.6
monocyte count
1
76.1
leukocyte count
3
75.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
apolipoprotein B mRNA editing enzyme catalytic subunit 3H
VGNC:6685
470214
Macaque
apolipoprotein B mRNA editing enzyme catalytic subunit 3H
723811
Species
Name
OMA
EggNOG
Inparanoid
Chimp
apolipoprotein B mRNA editing enzyme catalytic subunit 3H
Macaque
apolipoprotein B mRNA editing enzyme catalytic subunit 3H
Publication Statistics
PubMed Score 71.29
PubMed score by year
PubTator Score 38.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title