Tbio APOBEC3H DNA dC->dU-editing enzyme APOBEC-3H

Protein Summary

Description

DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. The A3H-var/haplotype 2 exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. This gene encodes a member of the apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3 family of proteins. The encoded protein is a cytidine deaminase that has antiretroviral activity by generating lethal hypermutations in viral genomes. Polymorphisms and alternative splicing in this gene influence its antiretroviral activity and are associated with increased resistence to human immunodeficiency virus type 1 infection in certain populations. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• Q6NTF7
• B0QYP0
• B0QYP1
• B7TQM5
• E9PF38
• M4W6S4
• Q5JYL9
• Q6IC87

Gene Name

• APOBEC3H

Ensembl ID

• ENST00000348946
• ENSP00000216123
• ENSG00000100298
• ENST00000401756
• ENSP00000385741
• ENST00000442487
• ENSP00000411754
• ENST00000613677
• ENSP00000483689

Symbol

• A3H
• ARP10
• ARP-10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.72
tissue sample	0.61
protein domain	0.58
cellular component	0.52
biological term	0.5

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Dc->du-editing Enzyme Apobec-3h

Protein / Hydrolase / Deaminase / Dna Dc->du-editing Enzyme Apobec-3h

DTO Classes

Protein / Enzyme / Hydrolase / Deaminase / Dna Dc->du-editing Enzyme Apobec-3h

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.7   (req: < 5)

Gene RIFs: 47   (req: <= 3)

Antibodies: 39   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.7   (req: >= 5)

Gene RIFs: 47   (req: > 3)

Antibodies: 39   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0