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Tdark
TRNP1
TMF-regulated nuclear protein 1

Protein Summary
Description
DNA-binding factor that regulates the expression of a subset of genes and plays a key role in tangential, radial, and lateral expansion of the brain neocortex. Regulates neural stem cells proliferation and the production of intermediate neural progenitors and basal radial glial cells affecting the process of cerebral cortex gyrification. May control the proliferation rate of cells by regulating their progression through key cell-cycle transition points (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000522111
  • ENSP00000429216
  • ENSG00000253368

Symbol
  • C1orf225
  • TRNP
  • TNRP
  • TRNP
  • C1orf225
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.67
transcription factor perturbation
0.61
tissue
0.58
cellular component
0.56
disease
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.4   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 35   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.4   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 35   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
3
2
4
86.6
urate measurement
2
2
2
81
serum gamma-glutamyl transferase measurement
2
2
2
78.7
heel bone mineral density
2
2
2
75.7
IGF-1 measurement
1
2
2
72.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
4
86.6
urate measurement
2
81
serum gamma-glutamyl transferase measurement
2
78.7
heel bone mineral density
2
75.7
IGF-1 measurement
2
72.4
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
TMF1-regulated nuclear protein 1
715405
Mouse
MGI:1916789
69539
Rat
RGD:1582917
688990
Pig
TMF1-regulated nuclear protein 1
100511386
Opossum
TMF1-regulated nuclear protein 1 [Source:HGNC Symbol;Acc:HGNC:34348]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
TMF1-regulated nuclear protein 1
Mouse
Rat
Pig
TMF1-regulated nuclear protein 1
Opossum
TMF1-regulated nuclear protein 1 [Source:HGNC Symbol;Acc:HGNC:34348]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6NT89-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (17)
1 – 10 of 17
ARHGAP11B
Tbio
Family:  Enzyme
Novelty:  0.0783727
Score:  0.623
Data Source:  STRINGDB
ADGRG1
Tbio
Family:  GPCR
Novelty:  0.00924718
Score:  0.612
Data Source:  STRINGDB
SMARCC2
Tbio
Family:  TF; Epigenetic
Novelty:  0.02625321
Score:  0.57
Data Source:  STRINGDB
TBC1D3
Tdark
Novelty:  0.1634209
Score:  0.557
Data Source:  STRINGDB
TBC1D3C
Tdark
Novelty:  0.16309186
Score:  0.555
Data Source:  STRINGDB
TBC1D3D
Tdark
Novelty:  0.16309186
Score:  0.555
Data Source:  STRINGDB
TMF1
Tbio
Novelty:  0.02543575
Score:  0.524
Data Source:  STRINGDB
FAM19A3
Tdark
Novelty:  0.37183557
Score:  0.491
Data Source:  STRINGDB
FAM81A
Tdark
Novelty:  0.6165039
Score:  0.49
Data Source:  STRINGDB
CNIH3
Tbio
Novelty:  0.22096987
Score:  0.49
Data Source:  STRINGDB
Publication Statistics
PubMed Score  9.40

PubMed score by year
PubTator Score  1.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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