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Tbio
HMBOX1
Homeobox-containing protein 1

Protein Summary
Description
Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA (PubMed:23813958, PubMed:23685356). Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation (PubMed:23685356). Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres (By similarity). Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs) (PubMed:23813958). Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination (PubMed:23813958). Might also be involved in the DNA damage response at telomeres (PubMed:23813958).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287701
  • ENSP00000287701
  • ENSG00000147421
  • ENST00000397358
  • ENSP00000380516
  • ENST00000521516
  • ENSP00000430238
  • ENST00000524238
  • ENSP00000430110
  • ENST00000558662
  • ENSP00000453211

Symbol
  • HOT1
  • TAH1
  • HOT1
  • PBHNF
  • HNF1LA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.83
transcription factor binding site profile
0.81
interacting protein
0.64
tissue sample
0.63
transcription factor
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.83   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 157   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.83   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (145)
Items per page:
1 – 5 of 145
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
miR-222 in Exercise-Induced Cardiac Growth
WikiPathways
miR-222 in Exercise-Induced Cardiac Growth
WikiPathways
Aryl Hydrocarbon Receptor
WikiPathways
Aryl Hydrocarbon Receptor
WikiPathways
Aryl Hydrocarbon Receptor
Name
Explore in Pharos
Explore in Source
miR-222 in Exercise-Induced Cardiac Growth
miR-222 in Exercise-Induced Cardiac Growth
Aryl Hydrocarbon Receptor
Aryl Hydrocarbon Receptor
Aryl Hydrocarbon Receptor
Gene Ontology Terms (22)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred by Curator (IC)
NTNU_SB
Protein-Protein Interactions (44)
1 – 10 of 44
MEMO1
Tbio
Novelty: 0.00852488
p_int: 0.999999981
p_ni: 1.5e-8
p_wrong: 4e-9
Score: 0.513
Data Source: BioPlex,STRINGDB
ASB7
Tdark
Novelty: 0.78440367
p_int: 0.999996221
p_ni: 0.000003778
p_wrong: 1e-9
Score: 0.197
Data Source: BioPlex,STRINGDB
ZAR1L
Tdark
Novelty: 0.09373976
p_int: 0.998496576
p_ni: 0.000043762
p_wrong: 0.001459662
Data Source: BioPlex
SPINK7
Tbio
Family: Enzyme
Novelty: 0.02271437
Score: 0.694
Data Source: STRINGDB
BRCA1
Tchem
Novelty: 0.00014684
Score: 0.687
Data Source: STRINGDB
PDCL2
Tbio
Novelty: 0.00280856
Score: 0.662
Data Source: STRINGDB
HIPK1
Tchem
Family: Kinase
Novelty: 0.20299662
Score: 0.62
Data Source: STRINGDB
GAR1
Tbio
Novelty: 0.47908745
Score: 0.611
Data Source: STRINGDB
POLI
Tchem
Family: Enzyme
Novelty: 0.0007183
Score: 0.597
Data Source: STRINGDB
ZBTB48
Tbio
Family: TF
Novelty: 0.10955569
Score: 0.588
Data Source: STRINGDB
Publication Statistics
PubMed Score  33.83

PubMed score by year
PubTator Score  20.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer