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Tbio
CYP4F22
Cytochrome P450 4F22

Protein Summary
Description
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19 and encodes an enzyme thought to play a role in the 12(R)-lipoxygenase pathway. Mutations in this gene are the cause of ichthyosis lamellar type 3. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269703
  • ENSP00000269703
  • ENSG00000171954
  • ENST00000601005
  • ENSP00000469866

Symbol
  • LI3
  • ARCI5
  • INLNE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.71
cell type or tissue
0.65
gene perturbation
0.65
molecular function
0.53
tissue sample
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.17   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 71   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.17   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (18)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Biological oxidations
Reactome
Cytochrome P450 - arranged by substrate type
Reactome
Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Biological oxidations
Cytochrome P450 - arranged by substrate type
Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
Disease
Protein-Protein Interactions (24)
1 – 10 of 24
NIPAL4
Tbio
Novelty: 0.04908645
Score: 0.917
Data Source: STRINGDB
LIPN
Tbio
Family: Enzyme
Novelty: 0.00181715
Score: 0.878
Data Source: STRINGDB
ALOXE3
Tbio
Family: Enzyme
Novelty: 0.03319677
Score: 0.831
Data Source: STRINGDB
ABCA12
Tbio
Family: Transporter
Novelty: 0.0030577
Score: 0.816
Data Source: STRINGDB
ALOX12B
Tbio
Family: Enzyme
Novelty: 0.03983447
Score: 0.812
Data Source: STRINGDB
PNPLA1
Tbio
Family: Enzyme
Novelty: 0.03557262
Score: 0.789
Data Source: STRINGDB
TGM1
Tchem
Family: Enzyme
Novelty: 0.00190135
Score: 0.731
Data Source: STRINGDB
CERS3
Tbio
Family: TF
Novelty: 0.06580864
Score: 0.695
Data Source: STRINGDB
ABHD5
Tbio
Family: Enzyme
Novelty: 0.00998736
Score: 0.623
Data Source: STRINGDB
ELOVL4
Tbio
Novelty: 0.00856302
Score: 0.554
Data Source: STRINGDB
Publication Statistics
PubMed Score  117.17

PubMed score by year
PubTator Score  50.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer