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Tdark
CGB2
Choriogonadotropin subunit beta variant 2

Protein Summary
Description
The beta subunit of chorionic gonadotropin (CGB) is encoded by six highly homologous and structurally similar genes that are arranged in tandem and inverted pairs on chromosome 19q13.3, and contiguous with the luteinizing hormone beta (LHB) subunit gene. The CGB genes are primarily distinguished by differences in the 5' untranscribed region. This gene was originally thought to be one of the two pseudogenes (CGB1 and CGB2) of CGB subunit, however, detection of CGB1 and CGB2 transcripts in vivo, and their presence on the polysomes, suggested that these transcripts are translated. To date, a protein product corresponding to CGB2 has not been isolated. The deduced sequence of the hypothetical protein of 132 aa does not share any similarity with that of functional CGB subunits (PMID:8954017). However, a 163 aa protein, translated from a different frame, is about the same size, and shares 98% identity with other CGB subunits. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359342
  • ENSP00000352295
  • ENSG00000104818
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.57
cell line
0.42
biological term
0.33
transcription factor binding site profile
0.2
PubMedID
0.18


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.8   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.8   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
AgBase
Protein-Protein Interactions (40)
1 – 10 of 40
CGB1
Tdark
Novelty: 0.16564171
p_int: 1
Data Source: BioPlex
KDM2A
Tchem
Family: Epigenetic
Novelty: 0.01990727
p_int: 0.999999227
p_ni: 7.73e-7
Data Source: BioPlex
WASF1
Tbio
Novelty: 0.00977488
p_int: 0.999619427
p_ni: 0.00038057
p_wrong: 3e-9
Data Source: BioPlex
NXN
Tbio
Novelty: 0.00968089
p_int: 0.993374873
p_ni: 0.006625127
Data Source: BioPlex
ABI1
Tbio
Novelty: 0.00796638
p_int: 0.993076926
p_ni: 0.006920581
p_wrong: 0.000002493
Data Source: BioPlex
MTA2
Tbio
Family: TF
Novelty: 0.01525806
p_int: 0.992441329
p_ni: 0.007558671
Data Source: BioPlex
ABI2
Tbio
Novelty: 0.02324355
p_int: 0.992406616
p_ni: 0.007593384
Data Source: BioPlex
NCKAP1
Tbio
Novelty: 0.03486454
p_int: 0.943545499
p_ni: 0.056454501
Data Source: BioPlex
CYFIP1
Tbio
Novelty: 0.01758346
p_int: 0.907692861
p_ni: 0.092307139
Data Source: BioPlex
CAMK1
Tchem
Family: Kinase
Novelty: 0.01239891
p_int: 0.895042242
p_ni: 0.104957756
p_wrong: 2e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  159.80

PubMed score by year
PubTator Score  4.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer