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Tdark
ZSCAN25
Zinc finger and SCAN domain-containing protein 25

Protein Summary
Description
May be involved in transcriptional regulation. This gene encodes a protein that bears some similarity to zinc finger proteins, which are involved in DNA binding and protein-protein interactions. Multiple alternatively spliced transcript variants have been identified, but the full-length nature for most of them has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334715
  • ENSP00000334800
  • ENSG00000197037
  • ENST00000394150
  • ENSP00000377706
  • ENST00000394152
  • ENSP00000377708

Symbol
  • ZNF498
  • ZNF498
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
histone modification site profile
0.81
transcription factor binding site profile
0.69
cell line
0.63
transcription factor
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
1
4
92.5
lymphocyte count
1
1
1
6.5
monocyte count
1
1
1
6.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
92.5
lymphocyte count
1
6.5
monocyte count
1
6.5
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger and SCAN domain containing 25
VGNC:4592
463577
Macaque
zinc finger and SCAN domain containing 25
709125
Mouse
MGI:3647079
666311
Rat
RGD:1308619
363872
Dog
zinc finger and SCAN domain containing 25
VGNC:48852
489853
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger and SCAN domain containing 25
Macaque
zinc finger and SCAN domain containing 25
Mouse
Rat
Dog
zinc finger and SCAN domain containing 25
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6NSZ9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Protein-Protein Interactions (41)
1 – 10 of 41
ZKSCAN8
Tbio
Family: TF
Novelty: 0.17881042
p_int: 0.994341348
p_ni: 0.005658405
p_wrong: 2.48e-7
Data Source: BioPlex
ZSCAN20
Tdark
Family: TF
Novelty: 0.37441538
p_int: 0.99423529
p_ni: 0.00576471
Data Source: BioPlex
RPS2
Tbio
Novelty: 0.00412313
p_int: 0.961530163
p_ni: 0.038469837
Data Source: BioPlex
HIST1H1A
Tbio
Novelty: 0.00123818
p_int: 0.953167742
p_ni: 0.046832221
p_wrong: 3.8e-8
Score: 0.234
Data Source: BioPlex,STRINGDB
RPL7A
Tbio
Novelty: 0.01674027
p_int: 0.947318382
p_ni: 0.052678756
p_wrong: 0.000002862
Data Source: BioPlex
E4F1
Tbio
Family: TF
Novelty: 0.02192338
p_int: 0.941841184
p_ni: 0.058158814
p_wrong: 2e-9
Data Source: BioPlex
ZBTB48
Tbio
Family: TF
Novelty: 0.07020518
p_int: 0.925616204
p_ni: 0.074382564
p_wrong: 0.000001232
Data Source: BioPlex
ZNF169
Tdark
Family: TF
Novelty: 1.09432767
p_int: 0.918043963
p_ni: 0.081956037
Data Source: BioPlex
RPL14
Tbio
Novelty: 0.01600377
p_int: 0.912178222
p_ni: 0.087819105
p_wrong: 0.000002673
Score: 0.217
Data Source: BioPlex,STRINGDB
SART3
Tbio
Novelty: 0.02353492
p_int: 0.885473108
p_ni: 0.114526892
Data Source: BioPlex
Publication Statistics
PubMed Score  1.00

PubMed score by year
PubTator Score  0.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer