Tbio RADX RPA-related protein RADX

Protein Summary

Description

Single-stranded DNA-binding protein recruited to replication forks to maintain genome stability (PubMed:28735897). Prevents fork collapse by antagonizing the accumulation of RAD51 at forks to ensure the proper balance of fork remodeling and protection without interfering with the capacity of cells to complete homologous recombination of double-strand breaks (PubMed:28735897).

Uniprot Accession IDs

• Q6NSI4
• H7BY89
• Q4G0L7
• Q5JQS1
• Q5JRF9
• Q6PHY5
• Q6PII9
• Q6PJU8
• Q9H7W5
• Q9NWA6

Gene Name

• RADX

Ensembl ID

• ENST00000372544
• ENSP00000361623
• ENSG00000147231
• ENST00000372548
• ENSP00000361628
• ENST00000461251
• ENSP00000432238

Symbol

• CXorf57
• CXorf57

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.77   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 23   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.77   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 23   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0